© 2008 Alexis Corporation
ALX-270-437
Revised 04-Jun-08
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Sirtuins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-437-M001
1 mg
110.00 USD
Product Specification
FORMULA:
C
13
H
13
ClN
2
O
MW:
248.7
CAS NUMBER:
49843-98-3
PURITY:
≥95%
APPEARANCE:
White to beige powder.
SOLUBILITY:
Soluble in DMSO (10mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months when stored at -20°C in the dark.
HANDLING:
Protect from light.
IDENTITY:
Identity determined by
1
H-NMR,
13
C-NMR and MS.
Product Description
Specific cell permeable inhibitor. Potent cell permeable and metabolically stable specific inhibitor of hSIRT1 (IC
50
=98nM
in vivo
/ IC
50
=38nM
in vitro
; compared to hSIRT2: IC
50
=19µM and hSIRT3: IC
50
=48µM) with no effect on human histone deacetylases (HDACs) class I and class II, nor NAD glycohydrolase (IC
50
>100µg). Inhibits the deacetylation of p53 (IC
50
=1µM).
Product Specific Literature References
Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1:
A.D. Napper, et al.; J. Med. Chem.
48
, 8045 (2005)
Abstract
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes:
J.C. Milne, et al.; Nature
450
, 712 (2007)
Abstract
Further Categories Containing This Product:
p53 Other Products
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