ALEXIS Biochemicals: Decoyinine

ALX-380-032

Revised 19-Mar-08

Decoyinine
SYNONYMS	Angustmycin A U-7984 9-(6-Deoxy-D-β-erythro-hex-5-en-2-ulofuranosyl)-adenine
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Other Signal Transduction Pathway Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-032-M001		1 mg	20.00 USD
ALX-380-032-M005		5 mg	60.00 USD

Product Specification

FORMULA:	C₁₁H₁₃N₅O₄
MW:	279.3
CAS NUMBER:	2004-04-8
RTECS:	AU6256000
SOURCE/HOST:	Natural fermentation product.
PURITY:	≥95%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO (warm), water or 100% ethanol; poorly soluble in methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored at +4°C. Stock solutions are stable for 3 months when stored at -20°C.

Product Description

Nucleoside antibiotic. Antitumor compound. Inhibitor of xanthosin monophosphate (XMP) aminase. Inhibitor of RNA synthesis. Specific inhibitor of GMP synthase. Reduces intracellular GTP levels.

Product Specific Literature References

Studies on a new antibiotic, angustmycin: H. Sakai, et al.; J. Antibiot. 7, 116 (1954) Abstract
Studies on a new antibiotic, angustmycin. I: H. Yuntsen, et al.; J. Antibiot. 7, 113 (1954) Abstract
Studies on angustmycin. III: H. Yuntsen, et al.; J. Antibiot. 9, 195 (1956) Abstract
On the studies of angustmycins. VI. Chemical structure of angustmycin A: H. Yuntsen; J. Antibiot. 11, 79 (1958) Abstract
Purine nucleosides. XXII. The synthesis of angustmycin A (decoyinine) and related unsaturated nucleosides: J.R. McCarthy, Jr., et al.; J. Am. Chem. Soc. 90, 4993 (1968) Abstract
Effects of several tumor-inhibitory antibiotics on immunological responses: H. Yamaki, et al.; J. Antibiot. 22, 315 (1969) Abstract
Halo sugar nucleosides. 5. Synthesis of angustmycin A and some base analogues: E.J. Prisbe, et al.; J. Org. Chem. 41, 1836 (1976) Abstract
A decrease in GTP content is associated with aerial mycelium formation in Streptomyces MA406-A-1: K. Ochi; J. Gen. Microbiol. 132, 299 (1986) Abstract
Extracellular control of spore formation in Bacillus subtilis: A.D. Grossman & R. Losick; PNAS 85, 4369 (1988) Abstract; Full Text
Nucleoside antibiotics: structure, biological activity, and biosynthesis: K. Isono; J. Antibiot. 41, 1711 (1988) Abstract
A target for carbon source-dependent negative regulation of the citB promoter of Bacillus subtilis: A. Fouret & A.L. Sonenshein; J. Bacteriol. 172, 835 (1990) Abstract; Full Text
Sporulation of Streptomyces venezuelae in submerged cultures: M.A. Glazebrook, et al.; J. Gen. Microbiol. 136, 581 (1990) Abstract
Conformational studies on some Cl’-branched beta-D-nucleosides by 1H-NMR spectroscopy and molecular mechanics calculations: J. Plavec, et al.; J. Biochem. Biophys. Meth. 26, 317 (1993) Abstract
Biochemical characterization of human GMP synthetase: J. Nakamura & L. Lou; J. Biol. Chem. 270, 7347 (1995) Abstract; Full Text
Guanine nucleotides guanosine 5’-diphosphate 3’-diphosphate and GTP co-operatively regulate the production of an antibiotic bacilysin in Bacillus subtilis: T. Inaoka, et al.; J. Biol. Chem. 278, 2169 (2003) Abstract; Full Text

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