ALEXIS Biochemicals: Cannabidiol

ALX-430-152

Revised 03-Apr-08

Cannabidiol
SYNONYMS	CBD 2-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products for Neurological Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-152-M001		1 mg
ALX-430-152-M005		5 mg

Product Specification

FORMULA:	C₂₁H₃₀O₂
MW:	314.5
CAS NUMBER:	13956-29-1
MERCK INDEX:	14: 1747
RTECS:	VH1600000
SOURCE/HOST:	Natural product.
PURITY:	≥98% (HPLC)
APPEARANCE:	White to pale yellow powder.
SOLUBILITY:	Soluble in DMSO, 100% ethanol or methanol; insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Non-psychotropic, anticonvulsive and neuroprotective in vivo. Shown to be a weak CB₁ receptor antagonist and inhibitor of anandamide uptake (IC₅₀=3.35mM and 27.5mM, respectively). Weak agonist of TRPV1 (EC₅₀=3.5mM).

Product Specific Literature References

Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants: A.J. Hampson, et al.; PNAS 95, 8268 (1998) Abstract; Full Text
The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis: A.M. Malfait, et al.; PNAS 97, 9561 (2000) Abstract; Full Text
Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite: A.B. El-Remessy, et al.; Am. J. Pathol. 163, 1997 (2003) Abstract; Full Text
Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines: P. Massi, et al.; J. Pharmacol. Exp. Ther. 308, 838 (2004) Abstract; Full Text
Effects of cannabidiol (CBD) on regional cerebral blood flow: J.A. Crippa, et al.; Neuropsychopharmacology 29, 417 (2004) Abstract; Full Text
Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression: E.J. Carrier, et al.; PNAS 103, 7895 (2006) Abstract; Full Text
Cannabidiol, unlike synthetic cannabinoids, triggers activation of RBL-2H3 mast cells: E. Del Giudice, et al.; J. Leukoc. Biol. 81, 1512 (2007) Abstract; Full Text

Further Categories Containing This Product:

Anandamide Uptake Inhibitors • TRPV1 Agonists and Antagonists/Related Products • Cannabinoid Receptor Agonists & Antagonists/Related Products • Natural Products - Antioxidants

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