© 2008 Alexis Corporation
ALX-350-134
Revised 28-May-08
Pyripyropene A
SYNONYMS
(+)-Pyripyropene A
PPPA
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Natural Products
Ordering Information
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Unit Price:
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ALX-350-134-C500
500 µg
190.00 USD
Product Specification
FORMULA:
C
31
H
37
NO
10
MW:
583.6
CAS NUMBER:
147444-03-9
SOURCE/HOST:
Isolated from
Aspergillus fumigatus
.
PURITY:
≥90% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in methanol or ethyl acetate; insoluble in water or hexane.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Highly specific inhibitor of acyl-coenzyme A:cholesterol acetyltransferase 2 (ACAT2).
Product Specific Literature References
Pyripyropenes, highly potent inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus:
S. Omura, et al.; J. Antibiot.
46
, 1168 (1993)
Abstract
Pyripyropenes, novel inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus. I. Production, isolation, and biological properties:
H. Tomoda, et al.; J. Antibiot.
47
, 148 (1994)
Abstract
Pyripyropenes, novel inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus. II. Structure elucidation of pyripyropenes A, B, C and D:
Y.K. Kim, et al.; J. Antibiot.
47
, 154 (1994)
Abstract
Aflavinines and other antiinsectan metabolites from the ascostromata of Eupenicillium crustaceum and related species:
H.J. Wang, et al.; Appl. Environ. Microbiol.
61
, 4429 (1995)
Abstract
;
Full Text
Total Synthesis of (+)-Pyripyropene A, a Potent, Orally Bioavailable Inhibitor of
Acyl-CoA:Cholesterol Acyltransferase:
T. Nagamitsu, et al.; J. Org. Chem.
60
, 8126 (1995)
Biosynthesis of Pyripyropene A:
H. Tomoda, et al.; J. Org. Chem.
61
, 882 (1996)
Meroterpenoids with various biological activities produced by fungi:
K. Shiomi, et al.; Pure Appl. Chem.
71
, 1059 (1999)
Full Text
A formal synthesis of (+)-pyripyropene A using a biomimetic epoxy-olefin cyclisation: effect of epoxy alcohol/ether on cyclisation efficiency:
V.K. Aggarwal, et al.; J. Chem. Soc. 3315 (1999)
Full Text
Mass-production of human ACAT-1 and ACAT-2 to screen isoform-specific inhibitor: a different substrate specificity and inhibitory regulation:
K.H. Cho, et al.; BBRC
309
, 864 (2003)
Abstract
Identification of ACAT1- and ACAT2-specific inhibitors using a novel, cell-based fluorescence assay: individual ACAT uniqueness:
A.T. Lada, et al.; J. Lipid Res.
45
, 378 (2004)
Abstract
;
Full Text
ACAT2 is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liver:
P. Parini, et al.; Circulation
110
, 2017 (2004)
Abstract
;
Full Text
Exploiting PdII and TiIII chemistry to obtain gamma-dioxygenated terpenoids: synthesis of rostratone and novel approaches to aphidicolin and pyripyropene A:
J. Justicia, et al.; J. Org. Chem.
70
, 8265 (2005)
Abstract
Total synthesis of alpha-pyrone meroterpenoids, novel bioactive microbial metabolites:
T. Sunazuka and S. Omura; Chem. Rev.
105
, 4559 (2005)
Abstract
Potential therapeutics for obesity and atherosclerosis: inhibitors of neutral lipid metabolism from microorganisms:
H. Tomoda & S. Omura; Pharmacol. Ther.
115
, 375 (2007)
Abstract
General Information
MANUFACTURER
Fungal strain courtesy of The Kitasato Institute, Tokyo.
Further Categories Containing This Product:
Cholesterol & Lipid Transport / Related Products
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