• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Toolbar - View Selection
 
Items 1 of 1
ALX-270-195 Revised 14-Jan-08
Bromoenol lactone
Add to Clipboard
SYNONYMS BEL
(E)-6-(Bromomethylene)tetrahydro-3-(1-naphthalenyl)-2H-pyran-2-one
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PLA2 Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-195-M005   5 mg 136.00 USD Add To Cart
Product Specification
FORMULA: C16H13BrO2
MW: 317.2
CAS NUMBER: 88070-98-8
PURITY: 98%
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, acetonitrile, DMSO or dimethyl formamide.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Before use, product should be dissolved in an organic solvent miscible with water. Further dilutions in aqueous buffers should be made just prior to performing experiment. Store aqueous solutions on ice and use within 12 hours. Although the aqueous solutions may be stable for more than 12 hours, we strongly recommend using a fresh preparation each day.
HAZARD: IRRITANT.

Product Description
Potent, irreversible inhibitor of Ca2+-independent phospholipase A2 (iPLA2). Also inhibits the macrophage PLA2 in a concentration-dependent manner. Effective enzyme-activated irreversible inhibitor of chymotrypsin.
Product Specific Literature References
Haloenol lactones. Potent enzyme-activated irreversible inhibitors for alpha-chymotrypsin: S.B. Daniels, et al.; J. Biol. Chem. 258, 15046 (1983) Abstract; Full Text
Suicide inhibition of canine myocardial cytosolic calcium-independent phospholipase A2. Mechanism-based discrimination between calcium- dependent and -independent phospholipases A2: S.L. Hazen, et al.; J. Biol. Chem. 266, 7227 (1991) Abstract; Full Text
Inhibition of macrophage Ca(2+)-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones: E.J. Ackermann, et al.; J. Biol. Chem. 270, 445 (1995) Abstract; Full Text
Inhibition of calcium-independent phospholipase A2 prevents arachidonic acid incorporation and phospholipid remodeling in P388D1 macrophages: J. Balsinde, et al.; PNAS 92, 8527 (1995) Abstract
 
 
© 2008 ALEXIS Corporation, Privacy Policy, Disclaimer, Feedbackanother CS2 website

Catalogs / Brochures

E-Newsletter

 

Shopping Cart [0]

 

Distributors

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.