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ALX-630-069 Revised 28-Jan-08
Chlorotoxin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-630-069-C500   500 µg 1'200.00 USD Add To Cart
Product Specification
SEQUENCE: H-Met-Cys-Met-Pro-Cys-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys-Asp-Asp-Cys-Cys-Gly-Gly-Lys-Gly-Arg-Gly-Lys-Cys-Tyr-Gly-Pro-Gln-Cys-Leu-Cys-Arg-NH2
(Disulfide bonds between Cys2-Cys19, Cys5-Cys28, Cys16-Cys33and Cys20-Cys35)
FORMULA: C158H249N52O48S11
MW: 3995.8
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: Lyophilized.
RECONSTITUTION: Reconstitute with distilled water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C.
Product Description
Potent neurotoxin. Small conductance Cl- channel blocker. Highly specific marker for glioma cells and tumors of neuroectodermal origin. Inhibits the activity of matrix metalloproteinase-2 (MMP-2).
Product Specific Literature References
Purification and characterization of chlorotoxin, a chloride channel ligand from the venom of the scorpion: J.A. DeBin, et al.; Am. J. Physiol. 264, C361 (1993) Abstract
NMR sequential assignments and solution structure of chlorotoxin, a small scorpion toxin that blocks chloride channels: G. Lippens, et al.; Biochemistry 34, 13 (1995) Abstract
Use of chlorotoxin for targeting of primary brain tumors
: L. Soroceanu, et al.; Cancer Res. 58, 4871 (1998) Abstract
Chlorotoxin, a scorpion-derived peptide, specifically binds to gliomas and tumors of neuroectodermal origin: S.A. Lyons, et al.; Glia 39, 162 (2002) Abstract
Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2: J. Deshane, et al.; J. Biol. Chem. 278, 4135 (2003) Abstract
Targeted delivery of antitumoral therapy to glioma and other malignancies with synthetic chlorotoxin (TM-601): A. N. Mamelak & D. B. Jacoby; Expert Opin. Drug Deliv. 4, 175 (2007), (Review) Abstract
Further Categories Containing This Product:
Cl- Channels
 
 
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