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ALX-270-370 Revised 01-Jul-08
NU1025
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SYNONYMS 8-Hydroxy-2-methylquinazoline-4-one
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-370-M001   1 mg 30.00 USD Add To Cart
ALX-270-370-M005   5 mg 90.00 USD Add To Cart
ALX-270-370-M025   25 mg 290.00 USD Add To Cart
Product Specification
FORMULA: C9H8N2O2
MW: 176.2
CAS NUMBER: 90417-38-2
PURITY: ≥98%
FORMULATION: Off-white to purple solid.
SOLUBILITY: Soluble in DMSO (25mg/ml). This solution can be further diluted 1:100 in tissue culture medium before use.
RECONSTITUTION: Reconstitute with DMSO.
SHIPPING: AMBIENT
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -20°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Packaged under inert gas. Protect from light.

Product Description
A potent poly(ADP-ribose) polymerase 1 (PARP-1) inhibitor (IC50=400nM) that potentiates the cytotoxicity of various DNA-active agents, including the DNA-methylating compound MTIC, the DNA strand break-inducing drug temozolomide (Prod. No. ALX-420-044), topotecan (Prod. No. ALX-350-133), bleomycin (Prod. No. ALX-630-107), and ionizing radiation effective in murine L1210 leukemia cells, CHO, and in a variety of human tumor cell lines.
Product Specific Literature References
Potentiation of temozolomide-induced cytotoxicity: a comparative study of the biological effects of poly(ADP-ribose) polymerase inhibitors: S. Boulton, et al.; Br. J. Cancer 72, 849 (1995) Abstract
Nephron-sparing surgery for renal cell carcinoma: J.H. Griffin & R.C. Flanigan; Tech. Urol.
Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064: K.J. Bowman, et al.; Br. J. Cancer 78, 1269 (1998) Abstract
Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP): R.J. Griffin, et al.; J. Med. Chem. 41, 5247 (1998) Abstract
Interactive effects of inhibitors of poly(ADP-ribose) polymerase and DNA-dependent protein kinase on cellular responses to DNA damage: S. Boulton, et al.; Carcinogenesis 20, 199 (1999) Abstract; Full Text
Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines: C.A. Delaney, et al.; Clin. Cancer Res. 6, 2860 (2000) Abstract; Full Text
Further Categories Containing This Product:
DNA Repair Other Products
 
 
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