ALEXIS Biochemicals: MAP4

ALX-550-118

Revised 28-Jan-05

MAP4
SYNONYMS	(S)-2-Amino-2-methyl-4-phosphonobutanoic acid α-Methyl-AP4
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	Glutamate Receptors (Metabotropic) / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-118-M005		5 mg	75.00 USD

Product Specification

FORMULA:	C₅H₁₂NO₅P
MW:	197.1
CAS NUMBER:	157381-42-5
PURITY:	≥96%
APPEARANCE:	White powder.
SOLUBILITY:	Soluble in dilute aqueous base.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C

Product Description

Selective agonist for group III mGluRs.

Product Specific Literature References

Actions of two new antagonists showing selectivity for different sub-types of metabotropic glutamate receptor in the neonatal rat spinal cord: D.E. Jane, et al.; Br. J. Pharmacol. 112, 809 (1994) Abstract
Phenylglycine derivatives as antagonists of metabotropic glutamate receptors: J. Watkins and G. Collingridge; TIPS 15, 333 (1994), (Review) Abstract
Antagonism of the synaptic depressant actions of L-AP4 in the lateral perforant path by MAP4: T.J. Bushell, et al.; Neuropharmacology 34, 239 (1995) Abstract
Pharmacological characterization of MCCG and MAP4 at the mGluR1b, mGluR2 and mGluR4a human metabotropic glutamate receptor subtypes: T. Knöpfel, et al.; Neuropharmacology 34, 1099 (1995) Abstract
Distinct presynaptic metabotropic receptors for L-AP4 and CCG1 on GABAergic terminals: pharmacological evidence using novel alpha-methyl derivative mGluR antagonists, MAP4 and MCCG, in the rat thalamu: T.E. Salt & S.A. Eaton; Neuroscience 65, 5 (1995) Abstract
Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists: J. Gomeza, et al.; Mol. Pharmacol. 50, 923 (1996) Abstract
Agonists of cyclic AMP-coupled metabotropic glutamate receptors in adult rat cortical slices: M.C. Kemp, et al.; Eur. J. Pharmacol. 309, 79 (1996) Abstract
Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes: N. Sekiyama, et al.; Br. J. Pharmacol. 117, 1493 (1996) Abstract
Neuroprotective effects of group III mGluR in traumatic neuronal injury: A.I. Faden, et al.; J. Neurotrauma 14, 885 (1997) Abstract

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