ALEXIS Biochemicals: Evodiamine

ALX-350-330

Revised 05-Apr-08

Evodiamine
SYNONYMS	8,13,13b,14-Tetrahydro-14-methylindolo[2’3’-3,4]pyrido[2,1-b]quinazolin-5-[7H]-one
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antitumor Reagents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-330-M010		10 mg	20.00 USD
ALX-350-330-M050		50 mg	50.00 USD

Product Specification

FORMULA:	C₁₉H₁₇N₃O
MW:	303.4
CAS NUMBER:	518-17-2
MERCK INDEX:	14: 3908
SOURCE/HOST:	Synthetic. Originally isolated from Evodia rutaecarpa.
PURITY:	≥98% (HPLC)
APPEARANCE:	Off-white to light yellow solid.
SOLUBILITY:	Soluble in DMSO (5mg/ml; warm).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

A cell permeable, non-pungent vanilloid receptor agonist that induces apoptosis. Inhibits nitric oxide (NO) production. Also inhibits tumor cell migration in vitro. Is effective against multidrug-resistant cancer cells.

Product Specific Literature References

Isolation of evodiamine, a powerful cardiotonic principle, from Evodia rutaecarpa Bentham (Rutaceae): N. Shoji, et al.; J. Pharm. Sci. 75, 612 (1986) Abstract
Inhibitory effect of dehydroevodiamine and evodiamine on nitric oxide production in cultured murine macrophages: W.F. Chiou, et al.; J. Nat. Prod. 60, 708 (1997) Abstract
Inhibitory effects of evodiamine on in vitro invasion and experimental lung metastasis of murine colon cancer cells: M. Ogasawara, et al.; Biol. Pharm. Bull. 24, 917 (2001) Abstract
Evodiamine, a constituent of Evodiae Fructus, induces anti-proliferating effects in tumor cells: X.F. Fei, et al.; Cancer Sci. 94, 92 (2003) Abstract
Evodiamine induces tumor cell death through different pathways: apoptosis and necrosis: Y. Zhang, et al.; Acta Pharmacol. Sin. 25, 83 (2004) Abstract
Antitumor mechanism of evodiamine, a constituent from Chinese herb Evodiae fructus, in human multiple-drug resistant breast cancer NCI/ADR-RES cells in vitro and in vivo: C.H. Liao, et al.; Carcinogenesis 26, 968 (2005) Abstract
Caspase-dependent and caspase-independent apoptosis induced by evodiamine in human leukemic U937 cells: T.J. Lee, et al.; Mol. Cancer Ther. 5, 2398 (2006) Abstract

Further Categories Containing This Product:

Natural Products - Nitric Oxide Pathway Modulators • TRPV1 Agonists and Antagonists / Related Products • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products for Neurological Research • MDR Inhibitors

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