ALEXIS Biochemicals: 12-Deoxyphorbol 13-phenylacetate

ALX-445-049

Revised 24-Oct-07

12-Deoxyphorbol 13-phenylacetate
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Phorbols / Phorbol Esters

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-445-049-M005		5 mg	220.00 USD

Product Specification

FORMULA:	C₂₈H₃₄O₆
MW:	466.6
CAS NUMBER:	58821-98-0
PURITY:	≥98%
SOLUBILITY:	Soluble in DMSO and ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	POTENTIAL TUMOR PROMOTER. IRRITANT.

Product Description

Metabolite of 12-deoxyphorbol 13-phenylacetate 20-acetate. Potent activator of protein kinase C (PKC). Induces the expression of HIV-1 in latently infected T cells.

Product Specific Literature References

Role of protein kinase C isozymes in activation of human immunodeficiency virus type 1 in chronically infected promonocytic cells: evidence against a role of PKC beta 1: C.H. Kim, et al.; Biochem. Biophys. Res. Commun. 199, 292 (1994) Abstract
Differential regulation by anti-tumor-promoting 12-deoxyphorbol-13-phenylacetate reveals distinct roles of the classical and novel protein kinase C isozymes in biological responses of primary mouse keratinocytes: Z. Szallasi, et al.; Mol. Pharmacol. 47, 258 (1995) Abstract
Activation of latent HIV-1 expression by the potent anti-tumor promoter 12-deoxyphorbol 13-phenylacetate: S. Bocklandt, et al.; Antiviral Res. 59, 89 (2003) Abstract

Further Categories Containing This Product:

PKC Activators

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