© 2008 Alexis Corporation
ALX-270-220
Revised 04-Nov-05
BAY 11-7085
SYNONYMS
(E)-3-(
t
-Butylphenylsulfonyl)-2-propenenitrile
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
NF-kB Pathway Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-220-M010
10 mg
60.00 USD
Product Specification
FORMULA:
C
13
H
15
NO
2
S
MW:
249.3
CAS NUMBER:
196309-76-9
PURITY:
≥98%
APPEARANCE:
White to off-white crystalline powder.
SOLUBILITY:
Soluble in DMSO or ethanol; insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Keep under inert gas.
Product Description
Has biological properties very similar to those of BAY 11-7082 (Prod. No.
ALX-270-219
). In addition, the product exhibits potent anti-inflammatory properties
in vivo
.
Product Specific Literature References
Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo
:
J.W. Pierce, et al.; J. Biol. Chem.
272
, 21096 (1997)
Abstract
;
Full Text
Pharmacologic interference with NF-kappaB activation attenuates central nervous system complications in experimental Pneumococcal meningitis:
U. Koedel, et al.; J. Infect Dis.
182
, 1437 (2000)
Abstract
Neuronal injury-induced expression and release of apolipoprotein E in mixed neuron/glia co-cultures: nuclear factor kappaB inhibitors reduce basal and lesion-induced secretion of apolipoprotein E:
V. Petegnief, et al.; Neuroscience
104
, 223 (2001)
Abstract
Further Categories Containing This Product:
Anti-inflammatory Agents Other Products
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