© 2008 Alexis Corporation
ALX-270-478
Revised 30-Jul-08
SB 225002
SYNONYMS
N-(2-Bromophenyl)-N’-(2-hydroxy-4-nitrophenyl)urea
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CXC Chemokines & Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-478-M001
1 mg
30.00 USD
ALX-270-478-M005
5 mg
90.00 USD
Product Specification
FORMULA:
C
13
H
10
BrN
3
O
4
MW:
352.1
CAS NUMBER:
182498-32-4
PURITY:
≥98% (HPLC)
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO (40mg/ml), 100% ethanol or methanol (15mg/ml); slightly soluble in acetonitrile (2mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
IDENTITY:
Identity determined by MS,
1
H-NMR and
13
C-NMR.
Product Description
Potent and selective antagonist of CXCR2 chemokine receptor (IC
50
=22nM). >150-fold more selective over CXCR1 receptor. Inhibits IL-8- (IC
50
=8nM) and GROα-mediated (IC
50
=10nM) calcium mobilisation. Prevents IL-8-induced neutrophil migration. Inhibits HIV replication in lymphocytes and macrophages.
Product Specific Literature References
Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration:
J.R. White, et al.; J. Biol. Chem.
273
, 10095 (1998)
Abstract
;
Full Text
Characterization of the molecular interactions of interleukin-8 (CXCL8), growth related oncogen alpha (CXCL1) and a non-peptide antagonist (SB 225002) with the human CXCR2:
J. Catusse, et al.; Biochem. Pharmacol.
65
, 813 (2003)
Abstract
A growth-related oncogene/CXC chemokine receptor 2 autocrine loop contributes to cellular proliferation in esophageal cancer:
B. Wang, et al.; Cancer Res.
66
, 3071 (2006)
Abstract
;
Full Text
Further Categories Containing This Product:
Interleukins Other Products
•
HIV / AIDS / Related Products
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