ALEXIS Biochemicals: BAY 43-9006

ALX-270-469

Revised 06-Jun-08

BAY 43-9006
SYNONYMS	N-[4-Chloro-3-(trifluoromethyl)phenyl]-([4-[2-(N-methylcarbamoyl)(4-pyridyloxy)]phenyl]amino)-carboxamide
PRODUCT LINE	Chemokines & Cytokines
PRODUCT CATEGORY	VEGFs & VEGF-Rs Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-469-M001		1 mg	60.00 USD
ALX-270-469-M005		5 mg	240.00 USD
ALX-270-469-M025		25 mg	720.00 USD

Product Specification

FORMULA:	C₂₁H₁₆ClF₃N₄O₃
MW:	464.8
CAS NUMBER:	284461-73-0
SOURCE/HOST:	Synthetic.
PURITY:	≥95% (HPLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO, 100% ethanol, methanol or ethyl acetate.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
IDENTITY:	Identity determined by ¹H-NMR.

Product Description

Broad-spectrum kinase inhibitor.

Product Specific Literature References

Sorafenib (BAY 43-9006, Nexavar((R))), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature: L. Adnane, et al.; Meth. Enzymol. 407, 597 (2005) Abstract
The kinase inhibitor Sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress: M. Rahmani, et al.; Mol. Cell. Biol. 27, 5499 (2007) Abstract

Further Categories Containing This Product:

Tyrosine Kinase Inhibitors

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