ALEXIS Biochemicals: 7BIO

ALX-430-149

Revised 23-Jun-08

7BIO
SYNONYMS	(2’Z, 3’E)-7-Bromoindirubin-3’-monoxime MLS2156
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Non-apoptotic Cell Death/Necrosis

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-149-M005		5 mg	80.00 USD
ALX-430-149-M025		25 mg	320.00 USD

Product Specification

FORMULA:	C₁₆H₁₀BrN₃O₂
MW:	356.2
PURITY:	≥95% (¹H-NMR)
APPEARANCE:	Dark brown solid.
SOLUBILITY:	Soluble in DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
HAZARD:	IRRITANT.

Product Description

Induces a rapid caspase-independent cell death process distinct from apoptosis. Demonstrated selective inhibition of aurora kinase B (IC₅₀=4.6µM) and aurora kinase C (IC₅₀=0.7µM) whereas the homologeous aurora kinase A is poorly inhibited.

Product Specific Literature References

3’-Substituted 7-halogenoindirubins, a new class of cell death inducing agents: Y. Ferandin, et al.; J. Med. Chem. 49, 4638 (2006) Abstract
7-Bromoindirubin-3’-oxime induces caspase-independent cell death: J. Ribas, et al.; Oncogene 25, 6304 (2006) Abstract
An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins: V. Myrianthopoulos, et al.; J. Med. Chem. 50, 4027 (2007) Abstract
7-Bromoindirubin-3’-oxime uncovers a serine protease-mediated paradigm of necrotic cell death: J. Ribas, et al.; Biochem. Pharmacol. 76, 39 (2008) Abstract

ALX-270-271	Indirubin-3'-monoxime
ALX-430-157	Me-7BIO
ALX-430-156	6BIO
ALX-270-296	Indirubin-5-sulfonic acid . sodium salt
ALX-270-361	Indirubin
ALX-270-424	5-Iodo-indirubin-3'-monoxime