ALEXIS Biochemicals: Erbstatin analog

ALX-270-098

Revised 16-Nov-06

Erbstatin analog
SYNONYMS	Methyl 2,5-dihydroxycinnamate
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	EGFR Kinase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-098-M005		5 mg	55.00 USD

Product Specification

FORMULA:	C₁₀H₁₀O₄
MW:	194.2
CAS NUMBER:	63177-57-1
PURITY:	≥98% (HPLC)
APPEARANCE:	Off-white to light brown crystalline solid.
SOLUBILITY:	Soluble in methanol, DMSO or dilute aqueous base.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light.
HAZARD:	TOXIC.

Product Description

Inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase. Considerably longer half-life in aqueous solution than erbstatin itself. Induces apoptosis.

Product Specific Literature References

Inhibition of epidermal growth factor-induced DNA synthesis by tyrosine kinase inhibitors: K. Umezawa, et al.; FEBS Lett. 260, 198 (1990) Abstract
Inhibition of epidermal growth factor receptor functions by tyrosine kinase inhibitors in NIH3T3 cells: K. Umezawa, et al.; FEBS Lett. 314, 289 (1992) Abstract
Induction of mouse thymocyte apoptosis by inhibitors of tyrosine kinases is associated with dephosphorylation of nuclear proteins: Y. Azuma, et al.; Cell Immunol. 152, 271 (1993) Abstract
Inhibition of Abelson oncogene function by erbstatin analogues: M. Kawada, et al.; Drugs Exp. Clin. Res. 19, 235 (1993) Abstract

Further Categories Containing This Product:

Tyrosine Kinase Inhibitors • Apoptosis Inducers & Inhibitors Other Products

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