• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Toolbar - View Selection
 
Items 1 of 1
ALX-804-369 Revised 13-Nov-08
Monoclonal Antibody to Dnmt1 (60B1220.1)
Add to Clipboard
SYNONYMS anti-DNA Methyltransferase-1 MAb (60B1220.1)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY DNA & RNA Methyl & Alkyl Transferases / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-369-C100   100 µg 293.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: 60B1220.1
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 637-650 of human Dnmt1 (DNA methyltransferase-1).
SPECIFICITY: Recognizes human, mouse and zebrafish Dnmt1.
APPLICATION: Immunocytochemistry (see [14])
Immunohistochemistry (1-2µg/ml) (paraffin sections (see [17]))
Immunoprecipitation (see [3,7]), Chromatin Immunoprecipitation (see [11]))
Western Blot (2-4µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 6 months when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
[1] Lsh, a member of the SNF2 family, is required for genome-wide methylation: K. Dennis, et al.; Genes Dev. 15, 2940 (2001) Abstract; Full Text
[2] The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription: R. Santoro, et al.; Nat. Genet. 32, 393 (2002) Abstract
[3] Farnesyltransferase inhibitor (L-744,832) restores TGF-beta type II receptor expression and enhances radiation sensitivity in K-ras mutant pancreatic cancer cell line MIA PaCa-2: R.A. Alcock, et al.; Oncogene 21, 7883 (2002) Abstract
[4] The Epstein-Barr virus oncogene product, latent membrane protein 1, induces the downregulation of E-cadherin gene expression via activation of DNA methyltransferases: C.N. Tsai, et al.; PNAS 99, 10084 (2002) Abstract; Full Text
[5] Age-dependent DNA methylation changes in the ITGAL (CD11a) promoter: Z. Zhang, et al.; Mech. Ageing Dev. 123, 1257 (2002) Abstract
[6] Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation: Y.W. Leu, et al.; Cancer Res. 63, 6110 (2003) Abstract
[7] Decrease of DNA methyltransferase 1 expression relative to cell proliferation in transitional cell carcinoma: F. Kimura, et al.; Int. J. Cancer 104, 568 (2003) Abstract
[8] Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns: J.M. Craig, et al.; Hum. Mol. Genet. 12, 3109 (2003) Abstract; Full Text
[9] Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells: H. Xin, et al.; J. Biol. Chem. 279, 9539 (2004) Abstract; Full Text
[10] Induction of DNA methylation and gene silencing by short interfering RNAs in human cells: H. Kawasaki and K. Taira; Nature 431, 211 (2004) Abstract
[11] Loss of estrogen receptor signaling triggers epigenetic silencing of downstream targets in breast cancer: Y.W. Leu, et al.; Cancer Res. 64, 8184 (2004) Abstract
[12] RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene re-expression in human lung and breast cancer cells: M. Suzuki, et al.; Cancer Res. 64, 3137 (2004) Abstract; Full Text
[13] Deregulation of DNA methyltransferases and loss of parental methylation at the insulin-like growth factor II (Igf2)/H19 loci in p53 knockout mice prior to tumor development: I.Y. Park, et al.; J. Cell Biochem. 94, 585 (2005) Abstract
[14] 5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal: K. Ghoshal, et al.; Mol. Cell. Biol. 25, 4727 (2005) Abstract
[15] Establishment and characterization of SRIK-NKL: a novel CD8+ natural killer/T cell line derived from a patient with leukemic phase of acute lymphoblastic lymphoma: B.I. Srivastava and M.D. Srivastava; Leuk. Res. 29, 771 (2005) Abstract
[16] Immunology of cutaneous vasculitis associated with both etanercept and infliximab: M.D. Srivastava, et al.; Scand. J. Immunol. 61, 329 (2005) Abstract
[17] An association of DNMT3b protein expression with P16INK4a promoter hypermethylation in non-smoking female lung cancer with human papillomavirus infection: T.S. Lin, et al.; Cancer Lett. 226, 77 (2005) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 

Your items will be kept only for the duration of your visit.