© 2008 Alexis Corporation
ALX-340-038 Revised 08-Jul-08
Leukotriene B4
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SYNONYMS LTB4
5,12-Dihydroxy-[S-[R*,S*-(E,Z,Z,E)]]-6,8,10,14-eicosatetraenoic acid
PRODUCT LINE Inflammation
PRODUCT CATEGORY Leukotrienes
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-340-038-C025   25 µg 170.00 USD Add To Cart
Product Specification
FORMULA: C20H32O4
MW: 336.5
CAS NUMBER: 71160-24-2
MERCK INDEX: 14: 5455
PURITY: ≥97%
FORMULATION: Liquid. Solution in ethanol.
SOLUBILITY: Soluble in DMSO or dimethyl formamide; slightly soluble in PBS, pH 7.2 (1mg/ml). Solvents should be free of oxygen, transition metal ions, and redox active compounds.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
HANDLING: Protect from light and oxygen.

Product Description
Activator of PPARα. Stimulates a number of leukocyte functions, including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis.
Product Specific Literature References
Leukotriene B4 and inflammatory disease: R.M. McMillan & S.J. Foster; Agents Actions 24, 114 (1988) Abstract
The PPARalpha-leukotriene B4 pathway to inflammation control: P.R. Devchand, et al.; Nature 384, 39 (1996) Abstract
Leukotriene B4: S.W. Crooks & R.A. Stockley; Int. J. Biochem. Cell Biol. 30, 173 (1998), (Review) Abstract
The peroxisome proliferator-activated receptor alpha (PPARalpha) ligand WY 14,643 does not interfere with leukotriene B4 induced adhesion of neutrophils to endothelial cells: M. Heimbürger & J. Palmblad; BBRC 249, 371 (1998) Abstract
Ligand selectivity of the peroxisome proliferator-activated receptor alpha: Q. Lin, et al.; Biochemistry 38, 185 (1999) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
PPAR Agonists
 
 
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