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ALX-270-402 Revised 08-Mar-05
TOFA
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SYNONYMS 5-(Tetradecyloxy)-2-furoic acid
RMI-14514
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Acetyl-Coenzyme A [Ac-CoA] Carboxylase / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-402-M010   10 mg 58.00 USD Add To Cart
ALX-270-402-M050   50 mg 230.00 USD Add To Cart
Product Specification
FORMULA: C19H32O4
MW: 324.5
CAS NUMBER: 54857-86-2
PURITY: ≥98% (1H-NMR)
APPEARANCE: White to off-white powder
SOLUBILITY: Soluble in dimethyl formamide, DMSO, 100% ethanol or methanol. Sparingly soluble in aqueous buffers.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C

Product Description
Potent, reversible and competitive inhibitor of acetyl-coenzyme A carboxylase (Ac-CoA carboxylase; ACC), a key enzyme involved in fatty acid biosynthesis. Rescues cancer cells from fatty acid synthase inhibitor C75 (Prod. No. ALX-270-286) cytotoxicity.
Product Specific Literature References
5-(Tetradecyloxy)-2-furancarboxylic acid and related hypolipidemic fatty acid-like alkyloxyarylcarboxylic acids: R.A. Parker, et al.; J. Med. Chem. 20, 781 (1977) Abstract
Interactions between fatty acid synthesis, oxidation, and esterification in the production of triglyceride-rich lipoproteins by the liver: N. Fukuda and J.A. Ontko; J. Lipid Res. 25, 831 (1984) Abstract
Inhibition of fatty acid synthesis decreases very low density lipoprotein secretion in the hamster: C.M. Arbeeny, et al.; J. Lipid Res. 33, 843 (1992) Abstract
Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors: T.M. Loftus, et al.; Science 288, 2379 (2000) Abstract
Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts: E.S. Pizer, et al.; Cancer Res. 60, 213 (2000) Abstract
Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells: W. Zhou, et al.; Cancer Res. 63, 7330 (2003) Abstract
C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism: L.E. Landree, et al.; J. Biol. Chem. 279, 3817 (2004) Abstract
General Literature References
Mechanistic diversity and regulation of Type II fatty acid synthesis: H. Marrakchi, et al; Biochem. Soc. Trans. 30, 1050 (2002) Abstract
Hypothalamic malonyl-CoA as a mediator of feeding behavior: Z. Hu, et al.; PNAS 100, 12624 (2003) Abstract
Fatty acid recycling in adipocytes: a role for glyceroneogenesis and phosphoenolpyruvate carboxykinase: C. Forest, et al.; Biochem. Soc. 31, 1125 (2003) Abstract
 
 
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