© 2008 Alexis Corporation
APO-54N-019 Revised 01-Apr-08
BAFF, Soluble (mouse) ELISA Kit
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SYNONYMS BlyS, Soluble (mouse) ELISA Kit
TALL-1, Soluble (mouse) ELISA Kit
THANK, Soluble (mouse) ELISA Kit
zTNF4, Soluble (mouse) ELISA Kit
TNFSF 13B/20, Soluble (mouse) ELISA Kit
CD257, Soluble (mouse) ELISA Kit
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY BAFF
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
APO-54N-019-KI01   1 Kit 630.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SENSITIVITY: 0.2ng/ml (range 0 to 20ng/ml)
QUANTITY: For 96 wells (~80 tests)
APPLICATION: For the quantitative determination of soluble mouse BAFF from biological fluids (serum and cell culture supernatant). Does not cross-react with human BAFF.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
Product Specific Literature References
In vitro and in vivo activation induces BAFF and APRIL expression in B cells: V.T. Chu, et al.; J. Immunol. 179, 5947 (2007) Abstract
General Information
BAFF (B cell activation factor of the TNF family, also known as BLyS or TALL1) is a cytokine expressed predominantly by cells of the immune system such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells, activated T cells and some malignant B cells. BAFF binds three distinct receptors (BAFF-R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF-R. BAFF is a master regulator of peripheral B cell survival, and also acts in processes such as immunoglobulin isotype switch and B cell co-stimulation. Besides its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of this membrane-bound protein, which can readily be released in a soluble form, leads to autoimmune disorders in mice. In humans, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases. 
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link : BAFF (mouse)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
The TNF family members BAFF and APRIL: the growing complexity: F. Mackay & C. Ambrose; Cytokine Growth Factor Rev. 14, 311 (2003) Abstract
TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma: M. Batten, et al.; J. Immunol. 172, 812 (2004) Abstract
The BAFF/APRIL system: life beyond B lymphocytes: L.G. Ng, et al.; Mol. Immunol. 42, 763 (2005) Abstract
BAFF augments certain Th1-associated inflammatory responses: A.P. Sutherland, et al.; J. Immunol. 174, 5537 (2005) Abstract
The BAFF/APRIL system: an important player in systemic rheumatic diseases: F. Mackay, et al.; Curr. Dir. Autoimmun. 8, 243 (2005) Abstract
Further Categories Containing This Product:
ELISA & EIA Kits
 
 
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