ALEXIS Biochemicals: RK-682

ALX-380-205

Revised 08-Apr-08

RK-682
SYNONYMS	3-Hexadecanoyl-5-hydroxymethyl-tetronic acid TAN 1364B CI 010
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Other Signal Transduction Pathway Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-205-MC05		0.5 mg	240.00 USD

Product Specification

FORMULA:	C₂₁H₃₆O₅
MW:	368.5
CAS NUMBER:	154639-24-4
SOURCE/HOST:	Isolated from Streptomyces sp. MST-AS5358.
PURITY:	≥95% (HPLC as Ca salt)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Tetronic acid derivative with potent activity against HIV-1 protease. Inhibits protein tyrosine phosphatase and heparanase.

Product Specific Literature References

3-Alkanoyl-5-hydroxymethyl tetronic acid homologues and resistomycin: new inhibitors of HIV-1 protease. I. Fermentation, isolation and biological activity: B.E. Roggo, et al.; J. Antibiot. (Tokyo) 47, 136 (1994) Abstract
The mechanism of ATP-induced long-term potentiation involves extracellular phosphorylation of membrane proteins in guinea-pig hippocampal CA1 neurons: S. Fujii, et al.; Neurosci. Lett. 187, 130 (1995) Abstract
RK-682, a potent inhibitor of tyrosine phosphatase, arrested the mammalian cell cycle progression at G1phase: T. Hamaguchi, et al.; FEBS Lett. 372, 54 (1995) Abstract; Full Text
Design and synthesis of a dimeric derivative of RK-682 with increased inhibitory activity against VHR, a dual-specificity ERK phosphatase: implications for the molecular mechanism of the inhibition: T. Usui, et al.; Chem. Biol. 8, 1209 (2001) Abstract; Full Text

Further Categories Containing This Product:

Antibiotics - Antiviral / Anti-HIV • Protein Tyrosine Phosphatases Other Products

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