ALEXIS Biochemicals: Monoclonal Antibody to Granzyme B (human) (B18.1)

ALX-804-121

Revised 18-Sep-07

Monoclonal Antibody to Granzyme B (human) (B18.1)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Granzyme Antibodies

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-121-C100	Purified	100 µg	290.00 USD
ALX-804-121F-T100	FITC	100 tests	350.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	B18.1
ISOTYPE:	Mouse IgG1
CONCENTRATION:	1mg/ml
PURITY:	≥95% (SDS-PAGE)
FORMULATION:	Liquid. Purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN:	Recombinant human granzyme B (aa 7-227).
SPECIFICITY:	Recognizes human granzyme B.
APPLICATION:	B18.1: Flow Cytometry Immunocytochemistry Immunohistochemistry (frozen sections, paraffin sections) Immunoprecipitation Western Blot B18.1-FITC: Flow Cytometry Immunocytochemistry Immunohistochemistry (frozen sections, paraffin sections)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	+4°C
USE/STABILITY:	Stable for at least 6 months after receipt when stored at +4°C undiluted.
HANDLING:	Do not freeze/thaw.

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Product Specific Literature References

Granzyme B and perforin can be used as predictive markers of acute rejection in heart transplantation: S. Legros-Maida, et al.; Eur. J. Immunol. 24, 229 (1994) Abstract
Perforin and granzyme B expression is associated with severe acute rejection. Evidence for in situ localization in alveolar lymphocytes of lung-transplanted patients: M.V. Clement, et al.; Transplantation 57, 322 (1994) Abstract
Granzyme B and perforin lytic proteins are expressed in CD34+ peripheral blood progenitor cells mobilized by chemotherapy and granulocyte colony-stimulating factor: C. Berthou, et al.; Blood 86, 3500 (1995) Abstract
Expansion of a peripheral blood perforin+ CD8+ T-cell subset in long- term surviving lung transplanted patients: C. Berthou, et al.; Transplant. Proc. 28, 1964 (1996) Abstract
Acquisition of granzyme B and Fas ligand proteins by human keratinocytes contributes to epidermal cell defense: C. Berthou, et al.; J. Immunol. 159, 5293 (1997) Abstract
Granzyme-mediated cytotoxicity does not involve the mannose 6-phosphate receptors on target cells: R. Dressel, et al.; J. Biol. Chem. 279, 20200 (2004) Abstract; Full Text

General Information

BACKGROUND/TECHNICAL INFORMATION	FITC-conjugated antibody: 1 test means: 1µl of a 0.1mg/ml stock solution were used to stain 200'000 cells in a sample volume of 50µl.
MANUFACTURER	Manufactured by Apotech Corporation.

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Monoclonal Antibodies

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