© 2008 Alexis Corporation
ALX-804-439 Revised 24-Apr-08
Monoclonal Antibody to Folate Receptor α (Mov18/ZEL)
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SYNONYMS anti-FRα MAb (Mov18/ZEL)
anti-Folate-binding Protein MAb (Mov18/ZEL)
anti-gp38 MAb (Mov18/ZEL)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Folic Acid & Folate Receptors/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-439-R100   100 µl 315.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Monkey
CLONE: Mov18/ZEL
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Purified from concentrated hybridoma cell culture supernatant.
FORMULATION: Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Membrane preparation from a human ovarian carcinoma specimen.
SPECIFICITY: Recognizes membrane-bound and soluble human and monkey folate receptor (FR) α. Does not cross-react with mouse or rat folate receptor. Does not cross-react with the β-isoform.
APPLICATION: Flow Cytometry
Immunocytochemistry
Immunohistochemistry (frozen sections; not recommended for paraffin sections)
Immunoprecipitation
Western Blot (avoid reducing reagents; use 0.1% SDS in transferring buffer).
Note: Suggested starting dilution for the above applications is 1-10µg/ml. Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for at least one year when stored undiluted at +4°C.
HANDLING: Avoid freeze/thaw cycles.
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Product Specific Literature References
Characterization of human ovarian carcinoma-associated antigens defined by novel monoclonal antibodies with tumor-restricted specificity: S. Miotti, et al.; Int. J. Cancer 39, 297 (1987) Abstract
Cloning of a tumor-associated antigen: MOv18 and MOv19 antibodies recognize a folate-binding protein: L.R. Coney, et al.; Cancer Res. 51, 6125 (1991) Abstract
Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues: S.D. Weitman, et al.; Cancer Res. 52, 3396 (1992) Abstract
Effect of hydrostatic pressure and cholesterol depletion on the expression of a tumor-associated antigen: N. Gesmundo, et al.; Eur. J. Biochem. 217, 337 (1993) Abstract
Isolation and biochemical characterization of the soluble and membrane forms of folate binding protein expressed in the ovarian carcinoma cell line IGROV1: A. Tomassetti, et al.; FEBS Lett. 317, 143 (1993) Abstract
Folate binding protein distribution in normal tissues and biological fluids from ovarian carcinoma patients as detected by the monoclonal antibodies MOv18 and MOv19: L.T. Mantovani, et al.; Eur. J. Cancer 30A, 363 (1994) Abstract
Role of folate receptor and reduced folate carrier in the transport of 5-methyltetrahydrofolic acid in human ovarian carcinoma cells: G. Corona, et al.; Int. J. Cancer 75, 125 (1998) Abstract
Molecular requirements for attachment of the glycosylphosphatidylinositol anchor to the human alpha folate receptor: A. Tomassetti, et al.; J. Cell Biochem. 72, 111 (1999) Abstract
General Information
The folate receptor is a highly selective tumor marker overexpressed in greater than 90% of ovarian carcinomas.
Further Categories Containing This Product:
Tumor Markers • Monoclonal Antibodies
 
 
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