ALEXIS Biochemicals: PRIMA-1

ALX-270-310

Revised 10-Jul-08

PRIMA-1
SYNONYMS	2,2-bis(Hydroxymethyl)-3-quinuclidinone
PRODUCT LINE	Cell Cycle
PRODUCT CATEGORY	p53 Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-310-M001		1 mg	23.00 USD
ALX-270-310-M005		5 mg	101.00 USD

Product Specification

FORMULA:	C₉H₁₅NO₃
MW:	185.2
CAS NUMBER:	5608-24-2
PURITY:	≥95%
APPEARANCE:	White to off-white crystalline solid.
SOLUBILITY:	25mg/ml soluble in 100% ethanol, DMSO or dimethyl formamide; 2.5mg/ml soluble in PBS, pH 7.2 .
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.

Product Description

Restores sequence-specific DNA binding and the active conformation to mutant p53 proteins in vitro and in vivo, thus triggering apoptosis of cancer cells.

Product Specific Literature References

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound: V.J. Bykov, et al.; Nat. Med. 8, 282 (2002) Abstract

Further Categories Containing This Product:

Antitumor Agents (Apoptosis Inducers)

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