© 2008 Alexis Corporation
ALX-210-765
Revised 07-Aug-08
Polyclonal Antibody to PAF Acetylhydrolase (human)
SYNONYMS
anti-Platelet Activating Factor Acetylhydrolase (human) PAb
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Platelet Activating Factors [PAF] & Receptors / Related Products
Ordering Information
Product Numbers:
Format:
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Unit Price:
Quantity:
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ALX-210-765-1
1 Vial
269.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.6mg/ml
FORMULATION:
Liquid. In 500μl TBS, pH 7.4, containing 50% glycerol, 0.5mg/ml BSA and 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 420-441 (T
420
NINTTNQHI
MLQNSSGIEKYN
441
) of C-terminal human plasma PAF-acetylhydrolase.
SPECIFICITY:
Recognizes human plasma PAF-acetylhydrolase. Detects a band of ~45kDa by Western blot. Does not cross-react with mouse, guinea pig, dog or chicken PAF-acetylhydrolase.
APPLICATION:
Western Blot (1:200)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
General Information
PAF-acetylhydrolase (PAF-AH) catalyzes the hydrolysis of the acetyl group at the
sn
-2 position of PAF to yield lyso-PAF and acetate, thereby inactivating PAF. Two main types of PAF-AH have been characterized, namely secreted (i.e. plasma) and intracellular enzymes, which are encoded on individual genes and share only 41% homology at the amino acid level [1-3]. Plasma PAF-AH is a 45kDa enzyme which is associated with the LDL fraction of plasma [2,4].
General Literature References
[1]
Platelet-activating factor acetylhydrolases :
D.M. Stafforini, et al.; J. Biol. Chem.
272
, 17895 (1997)
Abstract
;
Full Text
[2]
Anti-inflammatory properties of a platelet-activating factor acetylhydrolase:
L.W. Tjoelker, et al.; Nature
374
, 549 (1995)
Abstract
[3]
cDNA cloning and expression of intracellular platelet-activating factor (PAF) acetylhydrolase II. Its homology with plasma PAF acetylhydrolase:
K. Hattori, et al.; J. Biol. Chem.
271
, 33032 (1996)
Abstract
;
Full Text
[4]
Human plasma platelet-activating factor acetylhydrolase. Purification and properties:
D.M. Stafforini; J. Biol. Chem.
262
, 4223 (1987)
Abstract
;
Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
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