© 2008 Alexis Corporation
ALX-350-077
Revised 30-Jun-08
Swainsonine
SYNONYMS
8α,β-Octahydroindolizidine-1α,2α,8β-triol
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Antitumor Reagents
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-077-MC05
0.5 mg
85.00 USD
ALX-350-077-M001
1 mg
148.00 USD
Product Specification
FORMULA:
C
8
H
15
NO
3
MW:
173.2
CAS NUMBER:
72741-87-8
SOURCE/HOST:
Synthetic.
PURITY:
≥98% (TLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO, methanol or water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
IDENTITY:
Identity determined by
1
H-NMR.
Product Description
Reversibly inhibits the active site of lysosomal α-mannosidase. Also inhibits the growth of tumors and prevents metastasis in murine models. Could inhibit cell proliferation
in vitro
and the growth of human gastric carcinoma
in vivo
. Blocks the processing of high mannose oligosaccharides to form complex type oligosaccharides.
Product Specific Literature References
Inhibitors of glycoprotein synthesis:
A.D. Elbein; Meth. Enzymol.
98
, 135 (1983)
Abstract
Purification and characterization of Ca2+/calmodulin-dependent protein kinase V from rat cerebrum:
H. Mochizuki, et al.; J. Biol. Chem.
268
, 9143 (1993)
Abstract
;
Full Text
Swainsonine protects both murine and human haematopoietic systems from chemotherapeutic toxicity:
J.L. Klein, et al.; Br. J. Cancer
80
, 87 (1999)
Abstract
Swainsonine stimulates bone marrow cell proliferation and differentiation in different strains of inbred mice:
O.A. Oredipe, et al.; Pharmacol. Res.
47
, 69 (2003)
Abstract
Inhibition of the growth of human gastric carcinoma in vivo and in vitro by swainsonine:
J.Y. Sun, et al.; Phytomedicine
14
, 353 (2007)
Abstract
Further Categories Containing This Product:
Alkaloids
•
Natural Products with Antibiotic Activity
•
Glycosidases / Related Products
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