© 2008 Alexis Corporation
ALX-270-246
Revised 28-Sep-07
Purvalanol A
SYNONYMS
6-[(3-Chloro)anilino]-2(1R)-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDK & Cyclin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-246-M001
1 mg
55.00 USD
ALX-270-246-M005
5 mg
220.00 USD
Product Specification
FORMULA:
C
19
H
25
N
6
OCl
MW:
388.9
PURITY:
≥99%
APPEARANCE:
Off-white to yellow powder.
SOLUBILITY:
Soluble in DMSO, methanol or dichloromethane.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry. Keep under inert gas.
Product Description
Inhibitor of human CDK1 (IC
50
=4nM), CDK2/cyclin A (IC
50
=70nM), Cdc2/cyclin B, CDK2/cyclin E (IC
50
=35nM), CDK4/cyclin D1 (IC
50
=850nM) as well as CDK5/p35 (IC50=75nM). More membrane permeable than purvalanol B.
Product Specific Literature References
Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors:
N.S. Gray, et al.; Science
281
, 533 (1998)
Abstract
Up-regulation of cdc2 protein during paclitaxel-induced apoptosis:
P. Chadebech, et al.; Int. J. Cancer
87
, 779 (2000)
Abstract
Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons:
E.A. Monaco, 3rd, et al.; Biochem. Pharmacol.
67
, 1947 (2004)
Abstract
© 2008 ALEXIS Corporation,
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