© 2008 Alexis Corporation
ALX-804-808 Revised 13-Aug-07
Monoclonal Antibody to HSP90α/β (H90-10)
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SYNONYMS anti-Heat Shock Protein  90α/β MAb (H90-10)
anti-HSP84 MAb (H90-10)
anti-Heat Shock Protein 84 MAb (H90-10)
PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY HSP90 / HtpG / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-808-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Others
CLONE: H90-10
ISOTYPE: Mouse IgG2a
SOURCE/HOST: From mouse.
CONCENTRATION: 1mg/ml
PURITY: >95% (SDS-PAGE)
PURITY DETAIL: Purified from concentrated hybridoma tissue culture supernatant.
FORMULATION: Liquid. Purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN: Purified human HSP90β (heat shock protein 90β).
SPECIFICITY: Recognizes human, mouse and rabbit HSP90α and HSP90β.
APPLICATION: Immunocytochemistry (works on endogenous)
Immunoprecipitation (works on endogenous)
Western Blot (works on endogenous)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least one year after receipt when stored as recommended.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Analysis of FKBP51/FKBP52 chimeras and mutants for Hsp90 binding and association with progesterone receptor complexes: R.L. Barent, et al.; Mol. Endocrinol. 12, 342 (1998) Abstract; Full Text
Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome: M.A. Loo, et al.; EMBO J. 17, 6879 (1998) Abstract
The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties: S.J. Felts, et al.; J. Biol. Chem. 275, 3305 (2000) Abstract; Full Text
The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR: O. Donze, et al.; EMBO J. 20, 3771 (2001) Abstract
Hsp90 inhibition depletes Chk1 and sensitizes tumor cells to replication stress: S.J. Arlander, et al.; J. Biol. Chem. 278, 52572 (2003) Abstract; Full Text
GCUNC-45 Is a Novel Regulator for the Progesterone Receptor/hsp90 Chaperoning Pathway: A. Chadli, et al.; Mol. Cell. Biol. 26, 1722 (2006) Abstract
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Heat shock protein 90 as a molecular target for cancer therapeutics: J.S. Isaacs, et al.; Cancer Cell 3, 213 (2003), Review Abstract
Cancer: the rules of attraction: L. Neckers and Y.S. Lee; Nature 425, 357 (2003), Review Abstract
More than folding: localized functions of cytosolic chaperones: J.C. Young, et al.; TIBS 28, 541 (2003), Review Abstract
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress • Chaperone-mediated Autophagy [CMA] • Monoclonal Antibodies
 
 
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