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ALX-307-039 Revised 28-Nov-08
D-myo-Inositol 4,5-bisphosphate, L-α-Phosphatidyl-(1,2-dipalmitoyl)-
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SYNONYMS PtdIns(4,5)P2, (1,2-dipalmitoyl)-
L-α-Phosphatidyl-(1,2-dipalmitoyl)-D-myo-inositol 4,5-bisphosphate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Inositols & Inositolphosphates / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-307-039-C100   100 µg 95.00 USD Add To Cart
Product Specification
FORMULA: C41H81O19P3
MW: 971.0
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic.
IDENTITY: Identity determined by 1H-NMR, 31P-NMR, 13C-NMR and MS.

Product Description
The presence of 4,5-bisphosphate group on the inositol ring has been found critical for binding specifically to PH domains that are commonly present in signalling proteins, also found in cytoskeleton.
Product Specific Literature References
Structure of the binding site for inositol phosphate in a PH domain: M. Hyvonen, et al.; EMBO J. 14, 4676 (1995) Abstract
Inositolpolyphosphates and their binding proteins--a short review: B. Huisamen & A. Lochner; Mol. Cell. Biochem. 157, 229 (1996) Abstract
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate: T.F. Franke, et al.; Science 275, 665 (1997) Abstract
Phosphoinositide lipids as signaling molecules: common themes for signal transduction, cytoskeletal regulation, and membrane trafficking: T.F. Martin; Annu. Rev. Cell. Dev. Biol. 14, 231 (1998), (Review) Abstract
The synthesis and cellular roles of phosphatidylinositol 4,5- bisphosphate: A. Toker; Curr. Opin. Cell Biol. 10, 254 (1998) Abstract
Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5- bisphosphate: R. Rohatgi, et al.; J. Cell Biol. 150, 1299 (2000) Abstract
 
 
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