© 2008 Alexis Corporation
ALX-430-137
Revised 17-Apr-07
IM-54
SYNONYMS
2-(1
H
-Indol-3-yl)-3-pentylamino-maleimide
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Non-apoptotic Cell Death/Necrosis
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-430-137-M001
1 mg
30.00 USD
ALX-430-137-M025
25 mg
420.00 USD
Product Specification
FORMULA:
C
19
H
23
N
3
O
2
MW:
325.4
PURITY:
≥98% (HPLC)
APPEARANCE:
Yellow powder.
SOLUBILITY:
Soluble in DMSO (100mg/ml), dichloomethane, 100% ethanol or methanol (10mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Cell permeable inhibitor of necrosis. Selectively blocks oxidative stress-induced necrotic cell death (~3µM IM-54 prevented ~50% cell death in HL60 cells exposed to 100µM H
2
O
2
). Does not protect etoposide-induced apoptosis or display antioxidant properties. Does not affect S6K1 and PKC kinase activities at concentrations of 50µM.
Product Specific Literature References
Inhibition of hydrogen peroxide-induced necrotic cell death with 3-amino-2-indolylmaleimide derivatives:
K. Dodo, et al.; Bioorg. Med. Chem. Lett.
15
, 3114 (2005)
Abstract
Further Categories Containing This Product:
Cell Stress, Oxidative Stress & Redox Signalling Other Products
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