© 2008 Alexis Corporation
ALX-270-168
Revised 18-May-06
Tyrphostin AG 490
SYNONYMS
Tyrphostin B42
N-Benzyl-3,4-dihydroxy-benzylidenecyanoacetamide
α-Cyano-(3,4-dihydroxy)-]N-benzylcinnamamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-168-M005
5 mg
45.00 USD
ALX-270-168-M025
25 mg
190.00 USD
Product Specification
FORMULA:
C
17
H
14
N
2
O
3
MW:
294.3
CAS NUMBER:
133550-30-8
PURITY:
≥98%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO and acetone; slightly soluble in 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Selectively inhibits CDK2 activation leading to a potent cell cycle arrest at late G1 and S phase. Cell permeable inhibitor of JAK-2 tyrosine kinase. Does not significantly inhibit other kinases, such as Lck, Lyn, Btk, Syk or Src. Blocks IL-7 induced JAK kinase activity in T cells (JAK-1, JAK-3) and the consequent phosphorylation of PI-3 kinase. Valuable tool for studying the cellular role of JAK kinases in signal transduction.
Product Specific Literature References
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors:
A. Gazit, et al.; J. Med. Chem.
32
, 2344 (1989)
Abstract
Tyrosine phosphorylation is an obligatory event in IL-2 secretion [published erratum appears in J Immunol 1991 May 1;146(9):3260]:
A. Levitzki; Biochem. Pharmacol.
40
, 913 (1990)
Abstract
Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor is dependent on protein tyrosine kinase activity:
H. Dadi, et al.; Blood
84
, 1579 (1994)
Abstract
;
Full Text
JAK3 protein tyrosine kinase mediates interleukin-7-induced activation of phosphatidylinositol-3’ kinase
:
N. Sharfe, et al.; Blood
86
, 2077 (1995)
Abstract
;
Full Text
Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor:
N. Meydan, et al.; Nature
379
, 645 (1996)
Abstract
Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells:
R.A. Kirken, et al.; J. Leukoc. Biol.
65
, 891 (1999)
Abstract
JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response:
L.H. Wang, et al.; J. Immunol.
162
, 3897 (1999)
Abstract
JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells:
J. De Vos, et al.; Br. J. Haematol.
109
, 823 (2000)
Abstract
Further Categories Containing This Product:
Janus Kinases [JAKs] / Related Products
•
Tyrosine Kinase Inhibitors
•
CDK & Cyclin Inhibitors
•
Cell Cycle Blockers & Inhibitors / Related Products
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