ALEXIS Biochemicals: Tryprostatin A

ALX-380-090

Revised 12-Mar-08

Tryprostatin A
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics for Cytoskeletal Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-090-C500		500 µg	179.00 USD

Product Specification

FORMULA:	C₂₂H₂₇N₃O₃
MW:	381.5
SOURCE/HOST:	Isolated from Aspergillus fumigatus.
PURITY:	≥90%
APPEARANCE:	White powder.
SOLUBILITY:	Soluble in methanol, 100% ethanol or DMSO.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

Diketopiperazine. Arrests cell cycle progression at the G2/M phase. Inhibitor of MAP-dependent microtubule assembly. Inhibits the ABC-transporter breast cancer resistance protein (BCRP) and thereby reverses the resistance of cancer cells against antitumor drugs.

Product Specific Literature References

Tryprostatins A and B, novel mammalian cell cycle inhibitors produced by Aspergillus fumigatus: C.B. Cui, et al.; J. Antibiot. 48, 1382 (1995) Abstract
Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. I. Taxonomy, fermentation, isolation and biological properties: C.B. Cui, et al.; J. Antibiot. 49, 527 (1996) Abstract
Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. II. Physico-chemical properties and structures: C.B. Cui, et al.; J. Antibiot. 49, 534 (1996) Abstract
Tryprostatin A, a specific and novel inhibitor of microtubule assembly: T. Usui, et al.; Biochem. J. 333, 543 (1998) Abstract; Full Text
Reversal of breast cancer resistance protein-mediated drug resistance by tryprostatin A: H. Woehlecke, et al.; Int. J. Cancer 107, 721 (2003) Abstract

Further Categories Containing This Product:

MDR Inhibitors • Microtubule Modulators • Other Antibiotics for Cancer Research • Antibiotics for Cell Cycle Research

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