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ALX-801-013 Revised 02-Jul-08
Monoclonal Antibody to MRP1 (human) (MRPm6)
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SYNONYMS anti-Multidrug Resistance-associated Protein 1 (human) MAb (MRPm6)
anti-ABCC1 (human) MAb (MRPm6)
PRODUCT LINE Cancer
PRODUCT CATEGORY MDR-associated Proteins [MRPs] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-801-013-C250   250 µg 350.00 USD Add To Cart
ALX-801-013-C500   500 µg 630.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: MRPm6
ISOTYPE: Mouse IgG1
CONCENTRATION: ~500µg/ml
FORMULATION: Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide.
IMMUNOGEN: Recombinant human MRP1 (multidrug resistance-associated protein 1) (aa 1294-1531).
SPECIFICITY: Recognizes the internal epitope (P1511SDLLQQRGL1520) of human MRP1. Does not cross-react with human P-glycoprotein, MDR3 P-glycoprotein or human MRP2 (cMOAT) to MRP5.
APPLICATION: Flow Cytometry (cell permeabilization required)
Immunocytochemistry (cytospin preparations)
Immunohistochemistry (frozen sections, weak in paraffin sections)
Western Blot
Suggested starting dilution is 1:20. Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
Product Images
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Product Specific Literature References
Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies: M.J. Flens, et al.; Cancer Res. 54, 4557 (1994) Abstract
The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump: G.J. Zaman, et al.; PNAS 91, 8822 (1994) Abstract; Full Text
Expression of the multidrug resistance-associated protein (MRP) gene in human cancers: K. Nooter, et al.; Clin. Cancer Res. 1, 1301 (1995) Abstract
Membrane transport proteins associated with drug resistance expressed in human melanoma: D. Schadendorf, et al.; Am. J. Pathol. 147, 1545 (1995) Abstract
Tissue distribution of the multidrug resistance protein: M.J. Flens, et al.; Am. J. Pathol. 148, 1237 (1996) Abstract
Expression of the multidrug resistance-associated protein (MRP) gene in primary non-small-cell lung cancer: K. Nooter, et al.; Ann. Oncol. 7, 75 (1996) Abstract
Optimal immunocytochemical and flow cytometric detection of P-gp, MRP and LRP in childhood acute lymphoblastic leukemia: M.L. Den Boer, et al.; Leukemia 11, 1078 (1997) Abstract
Overexpression of lung-resistance protein and increased P-glycoprotein function in acute myeloid leukaemia cells predict a poor response to chemotherapy and reduced patient survival: A.G. Borg, et al.; Br. J. Haematol. 103, 1083 (1998) Abstract
Epitope mapping of monoclonal antibodies specific for the 190-kDa multidrug resistance protein (MRP): D.R. Hipfner, et al.; Br. J. Cancer 78, 1134 (1998) Abstract
Increased expression of multidrug resistance related proteins Pgp, MRP1, and LRP/MVP occurs early in colorectal carcinogenesis: G.A. Meijer, et al.; J. Clin. Pathol. 52, 450 (1999) Abstract
Evidence for the involvement of the glutathione pathway in drug resistance in AML: J.M. Sargent, et al.; Adv. Exp. Med. Biol. 457, 205 (1999) Abstract
The multidrug resistance protein is photoaffinity labeled by a quinoline-based drug at multiple sites: R. Daoud, et al.; Biochemistry 39, 6094 (2000) Abstract
Rhodamine 123 binds to multiple sites in the multidrug resistance protein (MRP1): R. Daoud, et al.; Biochemistry 39, 15344 (2000) Abstract
Expression of the multidrug resistance-associated protein in myelodysplastic syndromes: S. Poulain, et al.; Br. J. Haematol. 110, 591 (2000) Abstract
Cytofluorimetric analysis of a renal tubular cell line and its resistant counterpart: A. Rosati, et al.; Anticancer Res. 20, 3403 (2000) Abstract
Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies: G.L. Scheffer, et al.; Cancer Res. 60, 5269 (2000) Abstract; Full Text
(R)- and (S)-Verapamil Differentially Modulate the Multidrug-resistant Protein MRP1: T. Perrotton, et al.; J. Biol. Chem. 282, 31542 (2007) Abstract; Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
 
 

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