ALEXIS Biochemicals: Monoclonal Antibody to Calnexin (AF18)

ALX-804-014

Revised 20-Oct-08

Monoclonal Antibody to Calnexin (AF18)
SYNONYMS	anti-p88 MAb (AF18) anti-IP90 MAb (AF18)
PRODUCT LINE	Stress & Heat Shock Proteins
PRODUCT CATEGORY	Endoplasmatic Reticulum Stress

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-014-R100		100 µl	379.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse
CLONE:	AF18
ISOTYPE:	Mouse IgG1
FORMULATION:	Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN:	Focus human hepatoma cell line.
SPECIFICITY:	Recognizes human and mouse calnexin. Detects a band of ~90kDa by Western blot.
APPLICATION:	Immunocytochemistry (1:500) Immunoprecipitation Western Blot (1:4’000)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

Product Specific Literature References

The major histocompatibility complex class I antigen-binding protein p88 is the product of the calnexin gene: K. Galvin, et al.; PNAS 89, 8452 (1992) Abstract; Full Text
Formation of transitory intrachain and interchain disulfide bonds accompanies the folding and oligomerization of simian virus 40 Vp1 in the cytoplasm: P.P. Li, et al.; PNAS 99, 1353 (2002) Abstract; Full Text
FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction: B.N. Desai, et al.; PNAS 99, 4319 (2002) Abstract; Full Text
c-erbB-3: a nuclear protein in mammary epithelial cells: M. Offterdinger, et al.; J. Cell Biol. 157, 929 (2002) Abstract; Full Text
Cysteine string protein interacts with and modulates the maturation of the cystic fibrosis transmembrane conductance regulator: H. Zhang, et al.; J. Biol. Chem. 277, 28948 (2002) Abstract; Full Text
Sec13 shuttles between the nucleus and the cytoplasm and stably interacts with Nup96 at the nuclear pore complex: J. Enninga, et al.; Mol. Cell. Biol. 23, 7271 (2003) Abstract; Full Text
Transient calnexin interaction confers long-term stability on folded K+ channel protein in the ER: R. Khanna, et al.; J. Cell Sci. 117, 2897 (2004) Abstract; Full Text
An LQT mutant minK alters KvLQT1 trafficking: A. Krumerman, et al.; Am. J. Physiol. Cell Physiol. 286, C1453 (2004) Abstract
The stop transfer sequence of the human UDP-glucuronosyltransferase 1A determines localization to the endoplasmic reticulum by both static retention and retrieval mechanisms: L. Barre, et al.; Febs J. 272, 1063 (2005) Abstract; Full Text
The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma: K.T. Chin, et al.; Nucl. Acids Res. 33, 1859 (2005) Abstract; Full Text
Cysteine string protein monitors late steps in cystic fibrosis transmembrane conductance regulator biogenesis: H. Zhang, et al.; J. Biol. Chem. 281, 11312 (2006) Abstract; Full Text

General Information

Calnexin, also referred to as IP90 or p88, is a ~88kDa chaperone protein found in the endoplastmic reticulum. It binds with partially folded immunoglobulin proteins and retains them in the endoplastmic reticulum until they are completely folded.

Further Categories Containing This Product:

Monoclonal Antibodies

header picture © micronaut.ch, another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.