ALEXIS Biochemicals: Polyclonal Antibody to Progranulin (human)

ALX-210-465

Revised 23-Apr-08

Polyclonal Antibody to Progranulin (human)
SYNONYMS	anti-Proepithelin (human) PAb anti-PEPI (human) PAb anti-PC Cell-derived Growth Factor (human) PAb
PRODUCT LINE	Chemokines & Cytokines
PRODUCT CATEGORY	Progranulin/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-465-C100		100 µg	310.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
SOURCE/HOST:	From rabbit.
CONCENTRATION:	1mg/ml.
PURITY DETAIL:	Purified IgG.
FORMULATION:	Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:	Recombinant human progranulin.
SPECIFICITY:	Recognizes human progranulin.
APPLICATION:	ELISA (direct and indirect: 1:2’000-1:5’000) Western Blot (1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature). Optimal conditions must be determined individually for each application.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for 1-2 weeks when stored at +4°C.
HANDLING:	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

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General Information

Progranulin (PGRN) has been shown to be a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signalling cascades that control cell cycle progression and cell motility. PGRN has also been linked to tumorigenesis. The function of PGRN in the central nervous system (CNS) is also of interest, because mutations in the PGRN gene have been identified in cases of frontotemporal degeneration (FTD).

MANUFACTURER

Manufactured by AdipoGen, Inc.

General Literature References

Granulins, a novel class of peptide from leukocytes: A. Bateman, et al.; BBRC 173, 1161 (1990) Abstract
Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis: Z. He & A. Bateman; J. Mol. Med. 81, 600 (2003) Abstract
Progranulin is a mediator of the wound response: Z. He, et al.; Nat. Med. 9, 225 (2003) Abstract
Progranulin in frontotemporal lobar degeneration and neuroinflammation: Z. Ahmed, et al.; J. Neuroinflammation 4, 7 (2007) Abstract; Full Text
Progranulin: normal function and role in neurodegeneration: J.L. Eriksen & I.R. Mackenzie; J. Neurochem. 104, 287 (2008) Abstract

Further Categories Containing This Product:

Inflammation Other Products • Polyclonal Antibodies

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