ALEXIS Biochemicals: MY-5445

ALX-270-085

Revised 05-Feb-07

MY-5445
SYNONYMS	1-(3-Chlorophenylamino)-4-phenylphthalazine
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Phosphodiesterases / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-085-M001		1 mg	20.00 USD
ALX-270-085-M005		5 mg	70.00 USD

Product Specification

FORMULA:	C₂₀H₁₄ClN₃
MW:	331.8
CAS NUMBER:	78351-75-4
PURITY:	≥98%
APPEARANCE:	Off-white to yellow solid.
SOLUBILITY:	Soluble in DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
USE/STABILITY:	Stable for at least 1 year when stored at + 20°C. Store solutions at -20 °C for up to 3 months. Product is not sterile.

Product Description

Selective inhibitor of phosphodiesterase 5 (PDE5).

Product Specific Literature References

Effect of 1-(3-chloroanilino)-4-phenylphthalazine (MY-5445), a specific inhibitor of cyclic GMP phosphodiesterase, on human platelet aggregation: M. Hagiwara, et al.; J. Pharmacol. Exp. Ther. 228, 467 (1984) Abstract
Peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway: I.D. Durate, et al.; Eur. J. Pharmacol. 186, 289 (1990) Abstract
Inhibitory effects of natriuretic peptides on vasopressin neurons mediated through cGMP and cGMP-dependent protein kinase in vitro: N. Akamatsu, et al.; J. Neuroendocrinol. 5, 517 (1993) Abstract
cAMP modulates cGMP-mediated cerebral arteriolar relaxation in vivo: H.L. Xu, et al.; Am. J. Physiol. Heart Circ. Physiol. 287, H2501 (2004) Abstract; Full Text

Further Categories Containing This Product:

Phosphodiesterases / Related Products

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