ALEXIS Biochemicals: LL-Z1640-2

ALX-380-267

Revised 20-Nov-08

LL-Z1640-2
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Protein Kinase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-267-M001		1 mg	50.00 USD
ALX-380-267-M005		5 mg	200.00 USD

Product Specification

FORMULA:	C₁₉H₂₂O₇
MW:	362.4
CAS NUMBER:	66018-38-0
SOURCE/HOST:	Isolated from Deuteromycetes sp.
PURITY:	≥95% (HPLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in methanol, chloroform, acetone, DMSO or ethil acetate; insoluble in ethanol and n-hexane.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Inhibitor of the JNK/p38 pathways. Inhibits anisomycin-induced but not TNF-induced JNK/p38 activation. Potent protein kinase inhibitor.

Product Specific Literature References

A radicicol-related macrocyclic nonaketide compound, antibiotic LL-Z1640-2, inhibits the JNK/p38 pathways in signal-specific manner: K. Takehana, et al.; BBRC 257, 19 (1999) Abstract
Inhibition of HgCl2-induced mitogen-activated protein kinase activation by LL-Z1640-2 in CCRF-CEM cells: M. Matsuoka, et al.; Eur. J. Pharmacol. 409, 155 (2000) Abstract
Cadmium induces phosphorylation of p53 at serine 15 in MCF-7 cells: M. Matsuoka & H. Igisu; BBRC 282, 1120 (2001) Abstract
Effects of pentachlorophenol and tetrachlorohydroquinone on mitogen-activated protein kinase pathways in Jurkat T cells: B. Wispriyono, et al.; Environ. Health Perspect. 110, 139 (2002) Abstract; Full Text
Pharmacological inhibitors of MAPK pathways: J.M. English & M.H. Cobb; TIPS 23, 40 (2002), (Review) Abstract
Suppression of cadmium-induced JNK/p38 activation and HSP70 family gene expression by LL-Z1640-2 in NIH3T3 cells: N. Sugisawa, et al.; Toxicol. Appl. Pharmacol. 196, 206 (2004) Abstract
JNK (c-Jun NH2 terminal kinase) and p38 during ischemia reperfusion injury in the small intestine: T. Murayama, et al.; Transplantation 81, 1325 (2006) Abstract
Involvement of the extracellular signal-regulated protein kinase pathway in phosphorylation of p53 protein and exerting cytotoxicity in human neuroblastoma cells (SH-SY5Y) exposed to acrylamide: T. Okuno, et al.; Arch. Toxicol. 80, 146 (2006) Abstract
Protein kinases as small molecule inhibitor targets in inflammation: M. Gaestel, et al.; Curr. Med. Chem. 14, 2214 (2007), (Review) Abstract
Chemistry and biology of resorcylic acid lactones: N. Winssinger & S. Barluenga; Chem. Commun. 1, 22 (2007), (Review) Abstract; Full Text

Further Categories Containing This Product:

JNK [SAPK1] / Related Products

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