© 2008 Alexis Corporation
ALX-350-334
Revised 03-Apr-08
Ascochlorin
SYNONYMS
LL-Z 1272 γ
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antitumor Antibiotics
Ordering Information
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ALX-350-334-MC05
0.5 mg
320.00 USD
Product Specification
FORMULA:
C
23
H
29
ClO
4
MW:
404.9
CAS NUMBER:
26166-39-2
RTECS:
VH3707560
SOURCE/HOST:
Isolated from
Acremonium
sp. MST-FP1890.
PURITY:
≥95% (HPLC)
APPEARANCE:
White to light grey powder.
SOLUBILITY:
Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
Product Description
Antitumor antibiotic. Shows antiviral activity. Inhibitor or matrix metalloproteinase 9 (MMP-9). Reduces the inflammatory response to TNF-α in rat vascular smooth muscle cells. May be useful as an antiatherogenic agent.
Product Specific Literature References
Ascochlorin, a new antibiotic, found by the paper-disc agar-diffusion method. I. Isolation, biological and chemical properties of ascochlorin. (Studies on antiviral and antitumor antibiotics. I):
G. Tamura, et al.; J. Antibiot. (Tokyo)
21
, 539 (1968)
Abstract
Ascochlorin derivatives as ligands for nuclear hormone receptors:
M. Togashi, et al.; J. Med. Chem.
46
, 4113 (2003)
Abstract
Ascochlorin inhibits matrix metalloproteinase-9 expression by suppressing activator protein-1-mediated gene expression through the ERK1/2 signaling pathway: inhibitory effects of ascochlorin on the invasion of renal carcinoma cells:
S. Hong, et al.; J. Biol. Chem.
280
, 25202 (2005)
Abstract
;
Full Text
Selective cytotoxicity of ascochlorin in ER-negative human breast cancer cell lines:
K. Sakaguchi, et al.; BBRC
329
, 46 (2005)
Abstract
Ascochlorin suppresses oxLDL-induced MMP-9 expression by inhibiting the MEK/ERK signaling pathway in human THP-1 macrophages:
J.H. Kang, et al.; J. Cell. Biochem.
102
, 506 (2007)
Abstract
Further Categories Containing This Product:
MMP Inhibitors
•
Antibiotics for Cytoskeletal Research
•
Antibiotics for Inflammation Research
•
Antibiotics - Antiviral/Anti-HIV
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