© 2008 Alexis Corporation
ALX-270-413
Revised 23-Mar-06
N-Oxalyl-L-alanine
SYNONYMS
NOLA
N-Oxalyl-2S-alanine
NOxSA
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Hypoxia-inducible Factor [HIF] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-413-M010
10 mg
60.00 USD
ALX-270-413-M050
50 mg
180.00 USD
Product Specification
FORMULA:
C
5
H
7
NO
5
. H
2
O
MW:
161.1 . 18.0
PURITY:
≥98% (TLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Very hygroscopic.
Product Description
Cell permeable, competitive inhibitor of PHDs (prolyl hydroxylase domain-containing proteins; HIF-PHs). Less potent inhibitor of factor inhibiting HIF asparagine hydroxylase (FIH, IC
50
=2.5mM).
Product Specific Literature References
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
:
P. Jaakkola, et al.; Science
292
, 468 (2001)
Abstract
Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha
:
J.M. Elkins, et al.; J. Biol. Chem.
278
, 1802 (2003)
Abstract
© 2008 ALEXIS Corporation,
Privacy Policy
,
Disclaimer
,
Feedback
another
CS2
website
