ALEXIS Biochemicals: LAIR-1 (22-125) (human) (recombinant)

ALX-201-184

Revised 01-Mar-05

LAIR-1 (22-125) (human) (recombinant)
SYNONYMS	Leukocyte-associated Ig-like Receptor 1 (22-125) (human) (recombinant) CD305 (22-125) (human) (recombinant)
PRODUCT LINE	Immunology
PRODUCT CATEGORY	Killer Cell Immunoglobulin-like Receptors [KIRs] / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-201-184-C100		100 µg	325.00 USD

Product Specification

MW:	~11.7kDa.
SOURCE/HOST:	Produced in E. coli. Extracellular domain of human LAIR-1 (aa 22-125).
CONCENTRATION:	1mg/ml
PURITY:	≥95% (SDS-PAGE)
FORMULATION:	Liquid. In 20mM TRIS-HCl, pH 7.5, containing 50mM sodium chloride and 1mM EDTA.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

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General Information

LAIR-1 is a glycoprotein (~32kDa) expressed on the surface of the majority of human peripheral blood mononuclear leukocytes including T cells, B cells, NK cells, macrophages and dendritic cells. LAIR-1 functions as an inhibitory receptor in NK cells, T cells and B cells. It features of a leader sequence, extracellular domain, transmembrane domain and a cytoplasmic region.

General Literature References

LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes: L. Meyaard, et al.; Immunity 7, 283 (1997) Abstract
LAIR-1, a widely distributed human ITIM-bearing receptor on hematopoietic cells: L. Meyaard; Curr. Top. Microbiol. Immunol. 244, 151 (1999) Abstract
Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells: L. Meyaard, et al.; J. Immunol. 162, 5800 (1999) Abstract; Full Text
Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells: J.G. Sathish, et al.; J. Immunol. 166, 1763 (2001) Abstract; Full Text

Further Categories Containing This Product:

Immunoglobulin Superfamily Cell Adhesion Molecules [IgSF CAMs] / Related Products • Recombinant Proteins / Fusion Proteins

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