© 2008 Alexis Corporation
ALX-630-057
Revised 02-Nov-07
ω-Conotoxin MVIIC
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Neurotoxins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-630-057-C100
100 µg
340.00 USD
Product Specification
SEQUENCE:
H-Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-NH
2
(Disulfide bonds between Cys
1
-Cys
16
, Cys
8
-Cys
20
and Cys
15
-Cys
26
)
FORMULA:
C
106
H
178
N
40
O
32
S
7
MW:
2749.3
CAS NUMBER:
147794-23-8
SOURCE/HOST:
Synthetic. Originally isolated from
Conus magus
.
QUANTITY:
PURITY:
≥97%
APPEARANCE:
Lyophilized.
SOLUBILITY:
Soluble in water.
RECONSTITUTION:
Do not remove the cap. Inject distilled water into the vial using a calibrated syringe. Dissolve all contents thoroughly to receive a 0.1mM solution.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for 1 year when stored at -20°C. After reconstitution, stable for up to 2 weeks when stored at +4°C; up to 3 months when stored at -20°C.
HANDLING:
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
HAZARD:
POTENT NEUROTOXIN. VERY TOXIC.
Product Description
Neurotoxin. Potent and selective blocker of P/Q-type, voltage-gated Ca
2+
channels.
Not for sale in U.S.A.
Product Specific Literature References
Conotoxins
:
B.M. Olivera, et al.; J. Biol. Chem.
266
, 22067 (1991), (Minireview)
Abstract
;
Full Text
A new Conus peptide ligand for mammalian presynaptic Ca2+ channels
:
D.R. Hillyard, et al.; Neuron
9
, 69 (1992)
Abstract
Calcium channel diversity and neurotransmitter release: the omega-conotoxins and omega-agatoxins
:
B.M. Olivera, et al.; Ann. Rev. Biochem.
63
, 823 (1994), (Review)
Abstract
Roles of N-type and Q-type Ca2+ channels in supporting hippocampal synaptic transmission
:
D.B. Wheeler; Science
264
, 107 (1994)
Abstract
Inhibition of calcium channels in rat central and peripheral neurons by omega-conotoxin MVIIC:
S.I. McDonough, et al.; J. Neurosci.
16
, 2612 (1996)
Abstract
Structure-activity relationships of omega-conotoxins at N-type voltage-sensitive calcium channels:
K.J. Nielsen, et al.; J. Mol. Recognit.
13
, 55 (2000), (Review)
Abstract
Further Categories Containing This Product:
Ca2+ Channels (P/Q-type)
•
Peptides
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