ALEXIS Biochemicals: ANGPTL7 (human) (recombinant)

ALX-201-368

Revised 04-Apr-07

ANGPTL7 (human) (recombinant)
SYNONYMS	Angiopoietin-like Protein 7 (human) (recombinant) Cornea-derived Transcript 6 Protein (human) (recombinant)
PRODUCT LINE	Obesity & Adipokines
PRODUCT CATEGORY	Angiopoietin-like Proteins [ANGPTLs] / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-201-368-C010		10 µg	295.00 USD
ALX-201-368-C050		50 µg	795.00 USD

Product Specification

SOURCE/HOST:	Produced in HEK 293 cells. Human ANGPTL7 (angiopoietin-like protein 7) (aa 1-346) is fused at the C-terminus to a FLAG^®-tag.
CONCENTRATION:
PURITY:	≥90% (SDS-PAGE)
FORMULATION:	Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT:	<0.1EU/µg protein (LAL-test).
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Working aliquots are stable for up to 3 months when stored at -20°C.

Product Images

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General Information

Human ANGPTL7 is produced as a secreted glycoprotein with a molecular mass of 45kDa in SDS-PAGE analysis. Human mRNA is expressed in neural tissues, keratoconus cornea, trabecular meshwork, melanotic melanoma and uterus endometrial cancer, while mouse Angptl7 mRNA is expressed in four-cell embryos, synovial fibroblasts, thymus, uterus and testis. ANGPTL7 reduces tumor growth and aberrant blood vessel formation by inducing massive fibrosis in a mouse xenograft model [1]. It was reported that addition of ANGPTL7 results in a further increase in HSC activities. This suggests that ANGPTL7 may activate signal transduction pathways that cannot be activated by SCF, TPO, IGF-2 or FGF-1 [2]. Human ANGPTL7, characterized as potent target gene of WNT/ beta-catenin signalling pathway, is a pharmacogenomics target in the fields of oncology and regenerative medicine [3].
BACKGROUND/TECHNICAL INFORMATION	Swiss-Prot link O43827: Angiopoietin-related protein 7 (human) [Precursor] FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER	Manufactured by AdipoGen, Inc.

General Literature References

[1] The angiopoietin-like factor cornea-derived transcript 6 is a putative morphogen for human cornea: R. Peek, et al.; J. Biol. Chem. 277, 686 (2002) Abstract; Full Text
[2] Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells: C.C. Zhang, et al.; Nat. Med. 12, 240 (2006) Abstract
[3] Comparative integromics on Angiopoietin family members: Y. Katoh and M. Katoh; Int. J. Mol. Med. 17, 1145 (2006) Abstract

ALX-804-738	Monoclonal Antibody to ANGPTL7 (human) (Kairos 108-4)
ALX-201-395	ANGPTL7 (Fibrinogen-like Domain) (human) (recombinant)
ALX-210-453	Polyclonal Antibody to ANGPTL7 (human)