ALEXIS Biochemicals: Ratjadone C (native)

ALX-270-369

Revised 28-May-08

Ratjadone C (native)
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics for Cell Cycle Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-369-C005		5 µg	180.00 USD

Product Specification

FORMULA:	C₂₈H₄₀O₅
MW:	456.6
SOURCE/HOST:	Isolated from Sorangium cellulosum.
PURITY:	≥95%
FORMULATION:	Liquid. Solution in methanol (5µg in 1ml).
SOLUBILITY:	Soluble in methanol (>50mg/ml). Sparingly soluble in aqueous buffers (up to 10µg/ml in PBS).
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Acid and base sensitive. Unstable in acidic and alkaline buffer systems (pH <6 or >7). Stable in methanolic solution at -20°C.
HANDLING:	Protect from light.
HAZARD:	TOXIC.

Product Description

Cytotoxic secondary metabolite that inhibits cell growth of mammalian cell lines in the picomolar range (IC₅₀=0.2ng/ml with L929 mouse cells) including multidrug resistant (MDR) HeLa cells (IC₅₀=0.1ng/ml with KB-V1). Like leptomycin B (Prod. No. ALX-380-100), ratjadone C binds covalently to the nuclear export protein CRM1. It inhibits cargo protein binding to the leucine-rich nuclear export sequence and thereby blocks nuclear export.

Product Specific Literature References

Antibiotics from gliding bacteria, LXIII. Ratjadone: a new antifungal metabolite from Sorangium cellulosum: D. Schummer, et al.; Liebigs Ann. 685 (1995)
Ratjadon: a new antifungal compound from Sorangium cellulosum (myxobacteria) production, physico-chemical and biological properties: K. Gerth, et al.; J. Antibiot. (Tokyo) 48, 973 (1995) Abstract
The chemistry and biology of the leptomycin family: M. Kalesse & M. Christmann; Synthesis 8, 981 (2002) Abstract
Ratjadones inhibit nuclear export by blocking CRM1/exportin 1: M. Koster, et al.; Exp. Cell. Res. 286, 321 (2003) Abstract

Further Categories Containing This Product:

Cell Cycle Blockers & Inhibitors/Related Products • Nuclear Envelope & Nuclear Transport • Antibiotics - Antifungal • Antitumor Antibiotics • Antitumor Agents (Anti-proliferative)