© 2008 Alexis Corporation
ALX-270-292
Revised 09-Feb-05
1L-6-Hydroxymethyl-chiro-inositol-2-[(R)-2-O-methyl-3-O-octadecylcarbonate]
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phosphoinositide 3-kinase [PI(3)K]/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-292-M001
1 mg
85.00 USD
ALX-270-292-M005
5 mg
330.00 USD
Product Specification
FORMULA:
C
30
H
58
O
10
MW:
578.8
PURITY:
>98%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry.
Product Description
Potent inhibitor of Akt (PKB) (IC
50
=2.0µM). Weak inhibitor of PI(3)K (phosphoinositide 3-kinase) (IC
50
=83µM). Has been shown to inhibit the growth of the following cancer cell lines: HeLa (IC
50
=2.5µM), HT-29 (IC
50
=10µM), MCF-7 (IC
50
=1.2µM) and PC-3 (IC
50
=2.0µM).
Product Specific Literature References
3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, Akt, and cancer cell growth:
Y. Hu, et al.; J. Med. Chem.
43
, 3045 (2000)
Abstract
Further Categories Containing This Product:
Akt [PKB]/Related Products
•
Protein Kinase Inhibitors Other Products
•
Antitumor Agents (Enzyme Inhibitors)
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