ALEXIS Biochemicals: Monoclonal Antibody to Apaf-1 (18H2)

ALX-804-350

Revised 14-Aug-07

Monoclonal Antibody to Apaf-1 (18H2)
SYNONYMS	anti-Apoptosis Protease activating Factor 1 MAb (18H2)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Apaf-1

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-350-C100		100 µg	290.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse
CLONE:	18H2
ISOTYPE:	Rat IgG2a
CONCENTRATION:	1mg/ml
FORMULATION:	Liquid. Protein G purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN:	Recombinant mouse Apaf-1 (apoptosis protease-activating factor-1) (aa 1-97) containing the N-terminal CARD domain.
SPECIFICITY:	Recognizes the CARD domain of human and mouse Apaf-1. Does not cross-react with rat Apaf-1.
APPLICATION:	ELISA Immunocytochemistry Immunoprecipitation Western Blot
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

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Product Specific Literature References

Pro-apoptotic apoptosis protease-activating factor 1 (Apaf-1) has a cytoplasmic localization distinct from Bcl-2 or Bcl-x(L): G. Hausmann, et al.; J. Cell Biol. 149, 623 (2000) Abstract; Full Text
Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation: C.L. Scott, et al.; J. Cell Biol. 164, 89 (2004) Abstract; Full Text
Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death: V.S. Marsden, et al.; Blood 107, 1872 (2006) Abstract; Full Text

General Literature References

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade: P. Li, et al.; Cell 91, 479 (1997) Abstract
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3: H. Zou, et al.; Cell 90, 405 (1997) Abstract
Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development: F. Cecconi, et al.; Cell 94, 727 (1998) Abstract
Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation: Y. Hu, et al.; PNAS 95, 4386 (1998) Abstract; Full Text
Pro-apoptotic apoptosis protease-activating factor 1 (Apaf-1) has a cytoplasmic localization distinct from Bcl-2 or Bcl-x(L): G. Hausmann, et al.; J. Cell. Biol. 149, 623 (2000) Abstract; Full Text
Apaf1 in developmental apoptosis and cancer: how many ways to die?: F. Cecconi & P. Gruss; Cell. Mol. Life Sci. 58, 1688 (2001), (Review) Abstract

Further Categories Containing This Product:

Caspase Recruitment Domain [CARD] Proteins / Related Products • Monoclonal Antibodies

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