ALEXIS Biochemicals: Sulindac sulfide

ALX-430-106

Revised 31-Aug-04

Sulindac sulfide
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-106-M005		5 mg	32.00 USD
ALX-430-106-M025		25 mg	85.00 USD

Product Specification

FORMULA:	C₂₀H₁₇FO₂S
MW:	340.4
CAS NUMBER:	32004-67-4
PURITY:	≥98%
APPEARANCE:	Yellow-orange solid.
SOLUBILITY:	Soluble in 100% ethanol or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C

Product Description

Active metabolite of sulindac (Prod. Nr. ALX-430-105). NF-κB inhibitor. Induces apoptosis. Inhibits Ras signaling. Also inhibits cyclooxygenase (COX).

Product Specific Literature References

Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis: G.A. Piazza, et al.; Cancer Res. 55, 3110 (1995) Abstract
Sulindac sulfide inhibits Ras signaling: C. Herrmann, et al.; Oncogene 17, 1769 (1998) Abstract
Sulindac inhibits activation of the NF-kappaB pathway: Y. Yamamoto, et al.; J. Biol. Chem. 274, 27307 (1999) Abstract; Full Text

Further Categories Containing This Product:

COX Inhibitors • NF-kB Pathway Inhibitors • Apoptosis Inducers & Inhibitors Other Products

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