© 2008 Alexis Corporation
ALX-350-098
Revised 05-Apr-08
Ferutinin (high purity)
SYNONYMS
Tefestrol (high purity)
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Natural Products - DNA Regulation/Transcription
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-098-M001
1 mg
35.00 USD
ALX-350-098-M005
5 mg
100.00 USD
ALX-350-098-M010
10 mg
170.00 USD
Product Specification
FORMULA:
C
22
H
30
O
4
MW:
358.5
SOURCE/HOST:
Semisynthetic.
PURITY:
≥98%
SOLUBILITY:
Soluble in acetone, dichloromethane, DMSO or ethyl acetate.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Potent, naturally occuring non-steroid estrogenic compound. Agonist for estrogen receptor (ER) α and agonist/antagonist for ERβ with higher binding affinity than tamoxifen (Prod. No.
ALX-550-095
) for both ERs. Electrogenic Ca
2+
ionophore inducing mitochondrial depolarisation which can be completely blocked by cyclosporin A (Prod. No.
ALX-380-002
), suggesting that ferutinin opens the mitochondrial permeability transition pore (mPTP). In a concentration range of 1-50µM ferutinin increases the permeability of thymocytes, mitochondria, sarcoplasmic reticulum, liposomes and bilayer lipid membranes for Ca
2+
.
Product Specific Literature References
Ferutinine structure
:
A.I. Saidkhodjaev, et al.; Chem. Nat. Comp.
1
, 28 (1973)
Ionophoretic properties of ferutinin:
M.V. Zamaraeva, et al.; Cell Calcium
22
, 235 (1997)
Abstract
Influence of plant terpenoids on the permeability of mitochondria and lipid bilayers:
A.Y. Abramov, et al.; Biochim. Biophys. Acta
1512
, 98 (2001)
Abstract
Daucane phytoestrogens: a structure-activity study
:
G. Appendino, et al.; J. Nat. Prod.
65
, 1612 (2002)
Abstract
Terpenoids found in the umbelliferae family act as agonists/antagonists for ER(alpha) and ERbeta: differential transcription activity between ferutinine-liganded ER(alpha) and ERbeta
:
K. Ikeda, et al.; BBRC
291
, 354 (2002)
Abstract
Actions of ionomycin, 4-BrA23187 and a novel electrogenic Ca2+ ionophore on mitochondria in intact cells
:
A.Y. Abramov & M.R. Duchen; Cell Calcium
33
, 101 (2003)
Abstract
Further Categories Containing This Product:
Ionophores Other Products
•
MPTP [Mitochondrial Transition Pore]/Related Products
•
Estrogen & Estrogen Receptors/Related Products
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