ALEXIS Biochemicals: Monoclonal Antibody to TRIP-Br1 (TB1-27/2)

ALX-804-645

Revised 05-Mar-07

Monoclonal Antibody to TRIP-Br1 (TB1-27/2)
SYNONYMS	anti-SERTA Domain-containing Protein 1 MAb (TB1-27/2) anti-SEI-1 MAb (TB1-27/2) anti-CDK4-binding Protein p34SEI1 MAb (TB1-27/2) anti-Transcriptional Regulator Interacting with the PHD-bromodomain 1 MAb (TB1-27/2)
PRODUCT LINE	Cell Cycle
PRODUCT CATEGORY	CDKs & Cyclins Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-645-C050		50 µg	240.00 USD
ALX-804-645-C100		100 µg	360.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse Pig Monkey
CLONE:	TB1-27/2
ISOTYPE:	Mouse IgG2a.
CONCENTRATION:	1mg/ml.
FORMULATION:	Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to aa 27-42 (D²⁷PGHAAVAQAPPAVAS⁴²) of human TRIP-Br1 [SEI-1].
SPECIFICITY:	Recognizes human, mouse, pig and monkey TRIP-Br1.
APPLICATION:	Immunohistochemistry (1:200) Immunoprecipitation Western Blot (1:1’000-1:5’000)
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

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Product Specific Literature References

Exploiting the TRIP-Br family of cell cycle regulatory proteins as chemotherapeutic drug targets in human cancer: Z.J. Zang, et al.; (ahead of print), (2007)

General Information

TRIP-Br1 [SEI-1] functions as physiological integrator of transcriptional regulatory signals at E2F-responsive promoters to ensure proper execution of E2F-dependent cell cycle progression. TRIP-Br1 was recently defined as an oncogene.

General Literature References

RBT1, a novel transcriptional co-activator, binds the second subunit of replication protein A: J.M. Cho, et al.; Nucl. Acids Res. 28, 3478 (2000) Abstract; Full Text
TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1: S.I. Hsu, et al.; EMBO J. 20, 2273 (2001) Abstract; Full Text
The Drosophila gene taranis encodes a novel trithorax group member potentially linked to the cell cycle regulatory apparatus: S. Calgaro, et al.; Genetics 160, 547 (2002) Abstract; Full Text
Regulation of CREB-mediated transcription by association of CDK4 binding protein p34SEI-1 with CBP: T. Hirose, et al.; Int. J. Mol. Med. 11, 705 (2003) Abstract
TRIP-Br links E2F to novel functions in the regulation of cyclin E expression during cell cycle progression and in the maintenance of genomic stability: K.G. Sim, et al.; Cell Cycle 3, 1296 (2004) Abstract
The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner: J. Li, et al.; Biochemistry 43, 4394 (2004) Abstract
Expression of a human SOCS protein, HSOCP-1, in peripheral blood eosinophils from patients with atopic dermatitis: K. Ogawa, et al.; Int. Arch. Allergy Immunol. 134 Suppl 1, 2 (2004) Abstract
Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A): J. Li, et al.; Biochemistry 44, 13246 (2005) Abstract
SEI family of nuclear factors regulates p53-dependent transcriptional activation: R. Watanabe-Fukunaga, et al.; Genes Cells 10, 851 (2005) Abstract; Full Text
CDCA4 is an E2F transcription factor family-induced nuclear factor that regulates E2F-dependent transcriptional activation and cell proliferation: R. Hayashi, et al.; J. Biol. Chem. 281, 35633 (2006) Abstract; Full Text

Further Categories Containing This Product:

Tumor Suppressors / Related Products • Monoclonal Antibodies • Transcription Regulators Other Products

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