ALEXIS Biochemicals: Polyclonal Antibody to HERG1A (NT)

ALX-215-050

Revised 22-Feb-07

Polyclonal Antibody to HERG1A (NT)
SYNONYMS	anti-Erg1A (NT) PAb anti-Ether-a-go-go Related Protein 1A (NT) PAb anti-KCNH2 (Isoform A) (NT) PAb anti-Voltage-gated Potassium Channel Subfamily H Member 2 (Isoform A) (NT) PAb anti-Voltage-gated Potassium Channel Kv11.1 (Isoform A) (NT) PAb
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	K+ Channel Antibodies

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-215-050-R100		100 µl	270.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse
SOURCE/HOST:	From rabbit.
FORMULATION:	Liquid. Neat serum.
IMMUNOGEN:	Recombinant HERG1 (human ether-a-go-go related protein 1) (aa 1-135).
SPECIFICITY:	Recognizes N-terminal epitope of HERG1A and mouse Erg1A isoform.
APPLICATION:	Immunocytochemistry (1:50-1:200) Immunohistochemistry (frozen sections, paraffin sections) (1:100-1:400) Immunoprecipitation (5µl/1.5mg protein)
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

Product Specific Literature References

HERG potassium channels are more frequently expressed in human endometrial cancer as compared to non-cancerous endometrium: A. Cherubini, et al.; Br. J. Cancer 83, 1722 (2000) Abstract
Cell cycle-dependent expression of HERG1 and HERG1B isoforms in tumor cells: O. Crociani, et al.; J. Biol. Chem. 278, 2947 (2003) Abstract; Full Text
Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling: A. Cherubini, et al.; Mol. Biol. Cell 16, 2972 (2005) Abstract; Full Text
Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits: L. Guasti, et al.; J. Comp. Neurol. 491, 157 (2005) Abstract
Interneurons transiently express the ERG K+ channels during development of mouse spinal networks in vitro: F. Furlan, et al.; Neuroscience 135, 1179 (2005) Abstract

General Information

The ether-a-go-go related gene family of K⁺ channels (HERG/Erg) comprises three members, HERG1/Erg1, HERG2/Erg2, HERG3/Erg3. HERG channel activity is relevant to tumor cell biology. It controls cell proliferation, especially in leukaemias. HERG channels are thus considered novel diagnostic and prognostic factors in human cancers, as well as targets for anti-neoplastic therapies.

Further Categories Containing This Product:

Polyclonal Antibodies • Cancer Other Products • Cancer Other Products

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