ALEXIS Biochemicals: Polyclonal Antibody to SPRR3 (human) (4A)

ALX-210-902

Revised 24-Mar-05

Polyclonal Antibody to SPRR3 (human) (4A)
SYNONYMS	anti-Small Proline-rich Protein 3 (human) PAb (4A)
PRODUCT LINE	Cell Cycle
PRODUCT CATEGORY	Cell Differentiation

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-902-R100		100 µl	360.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
SOURCE/HOST:	From rabbit.
FORMULATION:	Liquid. Neat serum.
IMMUNOGEN:	Synthetic peptide corresponding to aa 115-130 (I¹¹⁵KVPDQGFIKFPEPGA¹³⁰) of human SPRR3 (small proline-rich protein 3).
SPECIFICITY:	Recognizes human SPRR3. Does not cross-react with SPRR1 or SPRR2.
APPLICATION:	Immunocytochemistry Immunohistochemistry (paraffin sections) Western Blot (1:2'000-1:4'000)
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored as recommended.
HANDLING:	Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.

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Product Specific Literature References

The small proline-rich proteins constitute a multigene family of differentially regulated cornified cell envelope precursor proteins: D. Hohl, et al.; J. Invest. Dermatol. 104, 902 (1995) Abstract
Expression of small proline rich proteins in neoplastic and inflammatory skin diseases: M. De Heller-Milev, et al.; Br. J. Dermatology 143, 733 (2000) Abstract

General Information

The formation of the cornified envelope (CE) during the late stages of epidermal differentiation is essential for epidermal barrier function and protects the body against environmental attack and water loss. Formation of the cornified envelope involves the replacement of the plasma membrane by cross-linkage of precursor proteins such as loricrin, involucrin and small proline rich proteins (SPRR). SPRR genes constitute a multigene family clustered within the epidermal differentiation complex on chromosome 1q21. This cluster contains two SPRR1 genes, seven SPRR2 genes and a single SPRR3 gene. SPRR gene products are differentially expressed in vivo and in vitro suggesting that the SPRR multigene family evolved to provide highly specialized cornified envelope precursor proteins in stratified epithelia. SPRR3 is highly expressed in oral and esophageal epithelium.

MANUFACTURER

Manufactured by Apotech Corporation.

General Literature References

Towards a better classification of erythrokeratodermias: D. Hohl; Br. J. Dermatology 143, 1133 (2000) Abstract