© 2008 Alexis Corporation
ALX-270-426
Revised 17-Jul-08
SAG
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Hedgehog [Hh] Signalling Pathway
Ordering Information
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Format:
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Unit Price:
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ALX-270-426-M001
1 mg
195.00 USD
Product Specification
FORMULA:
C
28
H
28
ClN
3
OS
MW:
490.1
CAS NUMBER:
364590-63-6
PURITY:
≥95%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water (5mg/ml) or DMSO (10mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Potent agonist of Hedgehog (Hh) signalling by activating the Smoothened (Smo) protein function.
Product Specific Literature References
Small molecule modulation of Smoothened activity:
J.K. Chen, et al.; PNAS
99
, 14071 (2002)
Abstract
;
Full Text
Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists:
M. Frank-Kamenetsky, et al.; J. Biol.
1
, 10 (2002)
Abstract
;
Full Text
Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2:
W. Chen, et al.; Science
306
, 2257 (2004)
Abstract
Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells:
R.B. Corcoran and M.P. Scott; PNAS
103
, 8408 (2006)
Abstract
;
Full Text
Smoothened Signal Transduction is Promoted by G-Protein Coupled Receptor Kinase 2:
A.R. Meloni et al.; Mol Cell Biol.
26
, 7550 (2006)
Abstract
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